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Disease Markers
Volume 2014, Article ID 798170, 6 pages
http://dx.doi.org/10.1155/2014/798170
Research Article

Expression of the Microtubule-Associated Protein MAP9/ASAP and Its Partners AURKA and PLK1 in Colorectal and Breast Cancers

1Institute of Human Genetics, UPR 1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
2Cancer Research Center of Toulouse, U1037, ERL5294, INSERM, CNRS and University Paul Sabatier, University of Toulouse, 205, route de Narbonne, 31077 Toulouse Cedex, France

Received 17 September 2013; Revised 25 March 2014; Accepted 14 April 2014; Published 30 April 2014

Academic Editor: George Perry

Copyright © 2014 Sylvie Rouquier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Cunningham, W. Atkin, H. Lenz et al., “Colorectal cancer,” The Lancet, vol. 375, no. 9719, pp. 1030–1047, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. M. Parkin, “Global cancer statistics in the year 2000,” Lancet Oncology, vol. 2, no. 9, pp. 533–543, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Sandouk, F. Al Jerf, and M. H. Al-Halabi, “Precancerous lesions in colorectal cancer,” Gastroenterology Research and Practice, vol. 2013, Article ID 457901, 11 pages, 2013. View at Publisher · View at Google Scholar
  4. M. M. Center, A. Jemal, R. A. Smith, and E. Ward, “Worldwide variations in colorectal cancer,” CA Cancer Journal for Clinicians, vol. 59, no. 6, pp. 366–378, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M.-J. Pillaire, J. Selves, K. Gordien et al., “A DNA replication signature of progression and negative outcome in colorectal cancer,” Oncogene, vol. 29, no. 6, pp. 876–887, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Sadanandam, C. A. Lyssiotis, K. Homicsko et al., “A colorectal cancer classification system that associates cellular phenotype and responses to therapy,” Nature Medicine, vol. 19, pp. 619–625, 2013. View at Publisher · View at Google Scholar
  7. H. T. Lynch and A. De la Chapelle, “Hereditary colorectal cancer,” New England Journal of Medicine, vol. 348, no. 10, pp. 919–932, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. W. M. Grady, “Molecular basis for subdividing hereditary colon cancer?” Gut, vol. 54, no. 12, pp. 1676–1678, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. A. S. Sameer, “Colorectal cancer: molecular mutations and polymorphisms,” Frontiers in Oncology, vol. 3, p. 114, 2013. View at Google Scholar
  10. B. Vogelstein, E. R. Fearon, S. R. Hamilton et al., “Genetic alterations during colorectal-tumor development,” New England Journal of Medicine, vol. 319, no. 9, pp. 525–532, 1988. View at Google Scholar · View at Scopus
  11. L. Mattera, F. Escaffit, M.-J. Pillaire et al., “The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways,” Oncogene, vol. 28, no. 12, pp. 1506–1517, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Sanz-Pamplona, A. Berenguer, D. Cordero et al., “Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review,” PLoS ONE, vol. 7, Article ID e48877, 2012. View at Google Scholar
  13. B. Orsetti, J. Selves, C. Bascoul-Mollevi et al., “Impact of chromosomal instability on colorectal cancer progression and outcome,” BMC Cancer, vol. 14, p. 121, 2014. View at Publisher · View at Google Scholar
  14. K. Michailidou, P. Hall, A. Gonzalez-Neira et al., “Large-scale genotyping identifies 41 new loci associated with breast cancer risk,” Nature Genetics, vol. 45, Article ID 361e1-2, pp. 353–361, 2013. View at Publisher · View at Google Scholar
  15. F. Bertucci, B. Orsetti, V. Nègre et al., “Lobular and ductal carcinomas of the breast have distinct genomic and expression profiles,” Oncogene, vol. 27, no. 40, pp. 5359–5372, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. F. J. Couch, X. Wang, L. McGuffog et al., “Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk,” PLoS Genetics, vol. 9, Article ID e1003212, 2013. View at Google Scholar
  17. M. M. Gaudet, K. B. Kuchenbaecker, J. Vijai et al., “Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk,” PLoS Genetics, vol. 9, Article ID e1003173, 2013. View at Google Scholar
  18. F. Lemée, V. Bergoglio, A. Fernandez-Vidal et al., “DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 30, pp. 13390–13395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Saffin, M. Venoux, C. Prigent et al., “ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 32, pp. 11302–11307, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Venoux, J. Basbous, C. Berthenet et al., “ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis,” Human Molecular Genetics, vol. 17, no. 2, pp. 215–224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Eot-Houllier, M. Venoux, S. Vidal-Eychenié, M. Hoang, D. Giorgi, and S. Rouquier, “Plk1 regulates both ASAP localization and its role in spindle pole integrity,” Journal of Biological Chemistry, vol. 285, no. 38, pp. 29556–29568, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Basbous, D. Knani, N. Bonneaud, D. Giorgi, J. M. Brondello, and S. Rouquier, “Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage,” Cell Cycle, vol. 11, no. 12, pp. 2380–2390, 2012. View at Google Scholar
  23. L. Fontenille, S. Rouquier, G. Lutfalla, and D. Giorgi, “Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development,” Cell Cycle, vol. 13, no. 7, pp. 1101–1114, 2014. View at Publisher · View at Google Scholar
  24. J. Hellemans, G. Mortier, A. De Paepe, F. Speleman, and J. Vandesompele, “qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data,” Genome Biology, vol. 8, no. 2, p. R19, 2007. View at Google Scholar · View at Scopus
  25. S. M. Lens, E. E. Voest, and R. H. Medema, “Shared and separate functions of polo-like kinases and aurora kinases in cancer,” Nature Reviews Cancer, vol. 10, no. 12, pp. 825–841, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. Schvartzman, R. Sotillo, and R. Benezra, “Mitotic chromosomal instability and cancer: mouse modelling of the human disease,” Nature Reviews Cancer, vol. 10, no. 2, pp. 102–115, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Venoux, K. Delmouly, O. Milhavet, S. Vidal-Eychenié, D. Giorgi, and S. Rouquier, “Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9),” BMC Genomics, vol. 9, p. 406, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Roché, P. Fumoleau, M. Spielmann et al., “Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 trial,” Journal of Clinical Oncology, vol. 24, no. 36, pp. 5664–5671, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Amat, F. Penault-Llorca, H. Cure et al., “Scarff-Bloom-Richardson (SBR) grading: a pleiotropic marker of chemosensitivity in invasive ductal breast carcinomas treated by neoadjuvant chemotherapy,” International Journal of Oncology, vol. 20, no. 4, pp. 791–796, 2002. View at Google Scholar · View at Scopus
  30. M. Martinazzi, C. Zampatti, F. Crivelli, A. Zampieri, and S. Martinazzi, “Scarff-Bloom-Richardson histoprognostic grading correlates with the immunohistochemical expressions of genomic alterrations in infiltrating ductal carcinomas (NOS) of the breast,” Oncology Reports, vol. 1, no. 6, pp. 1087–1091, 1994. View at Google Scholar · View at Scopus
  31. Y. Baba, K. Nosho, K. Shima et al., “Aurora-A expression is independently associated with chromosomal instability in colorectal cancer,” Neoplasia, vol. 11, no. 5, pp. 418–425, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Takahashi, B. Sano, T. Nagata et al., “Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers,” Cancer Science, vol. 94, no. 2, pp. 148–152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. M. M. Tanner, S. Grenman, A. Koul et al., “Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer,” Clinical Cancer Research, vol. 6, no. 5, pp. 1833–1839, 2000. View at Google Scholar · View at Scopus
  34. S. Anand, S. Penrhyn-Lowe, and A. R. Venkitaraman, “AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol,” Cancer Cell, vol. 3, no. 1, pp. 51–62, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Courjal, M. Cuny, C. Rodriguez et al., “DNA amplifications at 20q13 and MDM2 define distinct subsets of evolved breast and ovarian tumours,” British Journal of Cancer, vol. 74, no. 12, pp. 1984–1989, 1996. View at Google Scholar · View at Scopus
  36. M. A. Jordan and L. Wilson, “Microtubules as a target for anticancer drugs,” Nature Reviews Cancer, vol. 4, no. 4, pp. 253–265, 2004. View at Google Scholar · View at Scopus