Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2014, Article ID 912182, 6 pages
http://dx.doi.org/10.1155/2014/912182
Research Article

Impact of Molecular Testing in the Diagnosis of Thyroid Fine Needle Aspiration Cytology: Data from Mainland China

1Department of Pathology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Received 13 June 2013; Accepted 13 November 2013; Published 29 January 2014

Academic Editor: Silvia Persichilli

Copyright © 2014 Hui-qin Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Gharib and E. Papini, “Thyroid nodules: clinical importance, assessment, and treatment,” Endocrinology and Metabolism Clinics of North America, vol. 36, no. 3, pp. 707–735, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Führer, C. Mügge, and R. Paschke, “Questionnaire on management of nodular thyroid disease (Annual Meeting of the Thyroid Section of the German Society of Endocrinology 2003),” Experimental and Clinical Endocrinology and Diabetes, vol. 113, no. 3, pp. 152–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Filetti, C. Durante, and M. Torlontano, “Nonsurgical approaches to the management of thyroid nodules,” Nature Clinical Practice Endocrinology and Metabolism, vol. 2, no. 7, pp. 384–394, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. W. Baloch and V. A. LiVolsi, “Fine-needle aspiration of thyroid nodules: past, present, and future,” Endocrine Practice, vol. 10, no. 3, pp. 234–241, 2004. View at Publisher · View at Google Scholar
  5. H. Mazeh, N. Beglaibter, D. Prus, I. Ariel, and H. R. Freund, “Cytohistologic correlation of thyroid nodules,” American Journal of Surgery, vol. 194, no. 2, pp. 161–163, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. N. P. Ohori, M. N. Nikiforova, K. E. Schoedel et al., “Contribution of molecular testing to thyroid fine-needle aspiration cytology of “follicular lesion of undetermined significance/atypia of undetermined significance”,” Cancer Cytopathology, vol. 118, no. 1, pp. 17–23, 2010. View at Google Scholar · View at Scopus
  7. S. Cantara, M. Capezzone, S. Marchisotta et al., “Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 3, pp. 1365–1369, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. S. Jo, S. Huang, Y.-J. Kim et al., “Diagnostic value of pyrosequencing for the BRAFV600E mutation in ultrasound-guided fine-needle aspiration biopsy samples of thyroid incidentalomas,” Clinical Endocrinology, vol. 70, no. 1, pp. 139–144, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Marchetti, F. Lessi, C. M. Mazzanti et al., “A morpho-molecular diagnosis of papillary thyroid carcinoma: BRAF V600E detection as an important tool in preoperative evaluation of fine-needle aspirates,” Thyroid, vol. 19, no. 8, pp. 837–842, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. N. Nikiforova and Y. E. Nikiforov, “Molecular diagnostics and predictors in thyroid cancer,” Thyroid, vol. 19, no. 12, pp. 1351–1361, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Guan, M. Ji, R. Bao et al., “Association of high iodine intake with the T1799A BRAF mutation in papillary thyroid cancer,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 5, pp. 1612–1617, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. T. H. Kim, Y. J. Park, J. A. Lim et al., “The association of the BRAFV600E mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: a meta-analysis,” Cancer, vol. 118, no. 7, pp. 1764–1773, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Y. Park, J. M. Koh, Y. I. Kim et al., “Prevalences of Gsα, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population,” Clinical Endocrinology, vol. 49, no. 3, pp. 317–323, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Guerra, M. R. Sapio, V. Marotta et al., “Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application,” Endocrine Journal, vol. 58, no. 1, pp. 31–38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. Z. Zhu, R. Ciampi, M. N. Nikiforova, M. Gandhi, and Y. E. Nikiforov, “Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 9, pp. 3603–3610, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. K. J. Rhoden, K. Unger, G. Salvatore et al., “RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, pp. 2414–2423, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Romei and R. Elisei, “RET/PTC translocations and clinico-pathological features in human papillary thyroid carcinoma,” Frontiers in Endocrinology, vol. 3, article 54, 2012. View at Publisher · View at Google Scholar
  18. H. Namba, S. Yamashita, H.-C. Pei et al., “Lack of PTC gene (ret proto-oncogene rearrangement) in human thyroid tumors,” Endocrinologia Japonica, vol. 38, no. 6, pp. 627–632, 1991. View at Google Scholar · View at Scopus
  19. Y. Ishizaka, S. Kobayashi, T. Ushijima, S. Hirohashi, T. Sugimura, and M. Nagao, “Detection of ret(TPC)/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method,” Oncogene, vol. 6, no. 9, pp. 1667–1672, 1991. View at Google Scholar · View at Scopus
  20. J. H. Chung, J. R. Hahm, Y.-K. Min et al., “Detection of RET/PTC oncogene rearrangements in Korean papillary thyroid carcinomas,” Thyroid, vol. 9, no. 12, pp. 1237–1243, 1999. View at Google Scholar · View at Scopus
  21. R.-T. Liu, F.-F. Chou, C.-H. Wang et al., “Low prevalence of RET rearrangements (RET/PTC1, RET/PTC2, RET/PTC3, and ELKS-RET) in sporadic papillary thyroid carcinomas in Taiwan Chinese,” Thyroid, vol. 15, no. 4, pp. 326–335, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Xing, “BRAF mutation in thyroid cancer,” Endocrine-Related Cancer, vol. 12, no. 2, pp. 245–262, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. E. Nikiforov, “Molecular diagnostics of thyroid tumors,” Archives of Pathology and Laboratory Medicine, vol. 135, no. 5, pp. 569–577, 2011. View at Google Scholar · View at Scopus
  24. T. Fukushima, S. Suzuki, M. Mashiko et al., “BRAF mutations in papillary carcinomas of the thyroid,” Oncogene, vol. 22, no. 41, pp. 6455–6457, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. R.-T. Liu, C.-Y. Hou, H.-L. You et al., “Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan,” Thyroid, vol. 14, no. 8, pp. 616–621, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Yang, V. Schnadig, R. Logrono, and P. G. Wasserman, “Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations,” Cancer, vol. 111, no. 5, pp. 306–315, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. G. C. H. Yang, D. Liebeskind, and A. V. Messina, “Ultrasound-guided fine-needle aspiration of the thyroid assessed by Ultrafast Papanicolaou stain: data from 1135 biopsies with a two-to six-year follow-up,” Thyroid, vol. 11, no. 6, pp. 581–589, 2001. View at Google Scholar · View at Scopus
  28. E. L. Mazzaferri, “Management of a solitary thyroid nodule,” New England Journal of Medicine, vol. 328, no. 8, pp. 553–559, 1993. View at Publisher · View at Google Scholar · View at Scopus