The Clinicopathological Significance of miR-133a in Colorectal Cancer

Figure 2

Correlation of miR133a and its potential target genes in colorectal cancer. (a) There was a significant negative correlation shown between miR-133a and LASP1 mRNA expression: 𝑃=0.024, 𝛾=−0.23,   (𝑛=95). (b)–(d): (b) An overall significant correlation was found between miR-133a and CAV1 mRNA expression level: 𝑃=0.0089, 𝛾=0.27, (𝑛=91), (c) nonmetastatic: 𝑃=0.068, 𝛾=0.23, (𝑛=66), and (d) metastatic, a stronger positive correlation was determined between patients whom develop distant metastases: 𝑃=0.025, 𝛾=0.42, (𝑛=28). (e)–(g): (e) overall: 𝑃=0.037, 𝛾=−0.33, (𝑛=63), (f) nonmetastatic, a significant negative correlation was shown between miR-133a and FSCN1 mRNA expression levels that have not yet developed metastases: 𝑃=0.037, 𝛾=−0.33, (𝑛=41), (g) metastatic: 𝑃=0.56, 𝛾=0.13, (𝑛=24), 𝑛 = number of patients. Higher ΔΔ values indicate lower expression; positive values represent downregulation.

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