Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2014 (2014), Article ID 930206, 7 pages
http://dx.doi.org/10.1155/2014/930206
Review Article

Resistin: A Potential Biomarker for Periodontitis Influenced Diabetes Mellitus and Diabetes Induced Periodontitis

1Department of Periodontics, A.M.E’s Dental College and Hospital, Raichur, Karnataka 584103, India
2Department of Periodontics and Oral Implantology, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pune 411018, India
3Department of Prosthodontics, Dr. DY Patil Dental School, Knowledge City, Lohegaon, Pune 412105, India

Received 7 March 2013; Revised 1 July 2013; Accepted 12 November 2013; Published 12 February 2014

Academic Editor: Mariann Harangi

Copyright © 2014 Archana Devanoorkar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Zia, S. Khan, A. Bey, N. D. Gupta, and S. Mukhtar-Un-Nisar, “Oral biomarkers in the diagnosis and progression of periodontal diseases,” Biology and Medicine, vol. 3, no. 2, pp. 45–52, 2011. View at Google Scholar
  2. I. N. Holcomb, R. C. Kabakoff, B. Chan et al., “FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family,” The EMBO Journal, vol. 19, no. 15, pp. 4046–4055, 2000. View at Google Scholar · View at Scopus
  3. C. M. Steppan, S. T. Bailey, S. Bhat et al., “The hormone resistin links obesity to diabetes,” Nature, vol. 409, no. 6818, pp. 307–312, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. S. S. Pang and Y. Y. Le, “Role of resistin in inflammation and inflammation-related diseases,” Cellular & Molecular Immunology, vol. 3, no. 1, pp. 29–34, 2006. View at Google Scholar · View at Scopus
  5. D. T. Graves and D. Cochran, “The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction,” Journal of Periodontology, vol. 74, no. 3, pp. 391–401, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Nishimura, Y. Iwamoto, J. Mineshiba, A. Shimizu, Y. Soga, and Y. Murayama, “Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-α in a 2-way relationship,” Journal of Periodontology, vol. 74, no. 1, pp. 97–102, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Mengel, M. Bacher, and L. Flores-de-Jacoby, “Interactions between stress, interleukin-1β, interleukin-6 and cortisol in periodontally diseased patients,” Journal of Clinical Periodontology, vol. 29, no. 11, pp. 1012–1022, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Lehrke, M. P. Reilly, S. C. Millington, N. Iqbal, D. J. Rader, and M. A. Lazar, “An inflammatory cascade leading to hyperresistinemia in humans,” PLoS Medicine, vol. 1, pp. 161–168, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Furugen, H. Hayashida, N. Yamaguchi et al., “The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese,” Journal of Periodontal Research, vol. 43, no. 5, pp. 556–562, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. G. W. Taylor, “Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective,” Annals of Periodontology, vol. 6, no. 1, pp. 99–112, 2001. View at Google Scholar · View at Scopus
  11. N. Pischon, N. Heng, J.-P. Bernimoulin, B.-M. Kleber, S. N. Willich, and T. Pischon, “Obesity, inflammation, and periodontal disease,” Journal of Dental Research, vol. 86, no. 5, pp. 400–409, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. A. R. Pradeep, R. G. Manjunath, and R. Kathariya, “Progressive periodontal disease has a simultaneous incremental elevation of gingival crevicular fluid and serum CRP levels,” Journal of Investigative and Clinical Dentistry, vol. 1, no. 2, pp. 133–138.
  13. R. Kathariya, H. Jain, D. Gujar, A. Singh, H. Ajwani, and D. Mandhyan, “Pentraxins as key disease markers for periodontal diagnosis,” Disease Markers, vol. 34, no. 3, pp. 143–151, 2013. View at Google Scholar
  14. A. R. Pradeep, R. Kathariya, N. M. Raghavendra, and A. Sharma, “Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease,” Journal of Periodontology, vol. 82, no. 5, pp. 734–741, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. R. Pradeep, R. N. M. Raghavendra, M. V. R. Prasad, R. Kathariya, S. P. Patel, and A. Sharma, “Gingival crevicular fluid and serum visfatin concentration: their relationship in periodontal health and disease,” Journal of Periodontology, vol. 82, no. 9, pp. 1314–1319, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. N. M. Raghavendra, A. R. Pradeep, R. Kathariya, A. Sharma, N. S. Rao, and S. B. Naik, “Effect of non surgical periodontal therapy on gingival crevicular fluid and serum visfatin concentration in periodontal health and disease,” Disease Markers, vol. 32, no. 6, pp. 383–388, 2012. View at Google Scholar
  17. A. Sharma, A. R. Pradeep, N. M. Raghavendra, P. Arjun, and R. Kathariya, “Gingival crevicular fluid and serum cystatin c levels in periodontal health and disease,” Disease Markers, vol. 32, no. 2, pp. 101–107, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Devanoorkar, C. D. Dwarakanath, G. Gundanavar, S. R. Patil, and R. Kathariya, “Evaluation of serum resistin levels in periodontal health and disease and effects of non-surgical periodontal therapy on its levels,” Disease Markers, vol. 32, no. 5, pp. 289–294, 2012. View at Google Scholar
  19. A. R. Pradeep, R. Kathariya, P. Arjun Raju, R. Sushma Rani, A. Sharma, and N. M. Raghavendra, “Risk factors for chronic kidney diseases may include periodontal diseases, as estimated by the correlations of plasma pentraxin-3 levels: a case-control study,” International Urology and Nephrology, vol. 44, no. 3, pp. 829–839, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. A. R. Pradeep, N. M. Raghavendra, A. Sharma et al., “Association of serum and crevicular visfatin levels in periodontal health and disease with type 2 diabetes mellitus,” Journal of Periodontology, vol. 83, no. 5, pp. 629–634, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. C. M. Steppan and M. A. Lazar, “Resistin and obesity-associated insulin resistance,” Trends in Endocrinology and Metabolism, vol. 13, no. 1, pp. 18–23, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Liu, H. A. Baek, H. Yu et al., “FIZZ2/RELM-β induction and role in pulmonary fibrosis,” The Journal of Immunology, vol. 187, no. 1, pp. 450–461, 2011. View at Publisher · View at Google Scholar
  23. M. W. Rajala, S. Obici, P. E. Scherer, and L. Rossetti, “Adipose-derived resistin and gut-derived resistin-like molecule-β selectively impair insulin action on glucose production,” The Journal of Clinical Investigation, vol. 111, no. 2, pp. 225–230, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. C. M. Steppan and M. A. Lazar, “The current biology of resistin,” Journal of Internal Medicine, vol. 255, no. 4, pp. 439–447, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Filková, M. Haluzík, S. Gay, and L. Senolt, “The role of resistin as a regulator of inflammation: implications for various human pathologies,” Clinical Immunology, vol. 133, pp. 157–170, 2009. View at Google Scholar
  26. B. Sánchez-Solana, J. Laborda, and V. Baladrón, “Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor,” Molecular Endocrinology, vol. 26, no. 1, pp. 110–127, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Gerstmayer, D. Küsters, S. Gebel et al., “Identification of RELMγ, a novel resistin-like molecule with a distinct expression pattern,” Genomics, vol. 81, no. 6, pp. 588–595, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Tilg and A. R. Moschen, “Adipocytokines: mediators linking adipose tissue, inflammation and immunity,” Nature Reviews Immunology, vol. 6, no. 10, pp. 772–783, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. T. J. Guzik, D. Mangalat, and R. Korbut, “Adipocytokines–novel link between inflammation and vascular function?” Journal of Physiology and Pharmacology, vol. 57, no. 4, pp. 505–528, 2006. View at Google Scholar · View at Scopus
  30. E. Adeghate, “An update on the biology and physiology of resistin,” Cellular and Molecular Life Sciences, vol. 61, no. 19-20, pp. 2485–2496, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. E. D. Muse, S. Obici, S. Bhanot et al., “Role of resistin in diet-induced hepatic insulin resistance,” The Journal of Clinical Investigation, vol. 114, no. 2, pp. 232–239, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Satoh, M. T. A. Nguyen, P. D. G. Miles, T. Imamura, I. Usui, and J. M. Olefsky, “Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats,” The Journal of Clinical Investigation, vol. 114, no. 2, pp. 224–231, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Bajaj, S. Suraamornkul, L. J. Hardies, T. Pratipanawatr, and R. A. DeFronzo, “Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients,” International Journal of Obesity, vol. 28, no. 6, pp. 783–789, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Sánchez-Solana, J. Laborda, and V. Baladrón, “Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor,” Molecular Endocrinology, vol. 26, no. 1, pp. 110–127, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Sánchez-Solana, J. Laborda, and V. Baladrón, “Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor,” Molecular Endocrinology, vol. 26, no. 1, pp. 110–127, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Zhou, Y. Li, T. Xia, S. Feng, X. Chen, and Z. Yang, “Resistin overexpression impaired glucose tolerance in hepatocytes,” European Cytokine Network, vol. 17, no. 3, pp. 189–195, 2006. View at Google Scholar · View at Scopus
  37. K. M. Utzschneider, D. B. Carr, J. Tong et al., “Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans,” Diabetologia, vol. 48, no. 11, pp. 2330–2333, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. C. S. Ritchie, “Obesity and periodontal disease,” Periodontology 2000, vol. 44, no. 1, pp. 154–163, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. E. Field, E. H. Coakley, A. Must et al., “Impact of overweight on the risk of developing common chronic diseases during a 10-year period,” Archives of Internal Medicine, vol. 161, no. 13, pp. 1581–1586, 2001. View at Google Scholar · View at Scopus
  40. S. G. Wannamethee and A. G. Shaper, “Weight change and duration of overweight and obesity in the incidence of type 2 diabetes,” Diabetes Care, vol. 22, no. 8, pp. 1266–1272, 1999. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Kaser, A. Kaser, A. Sandhofer, C. F. Ebenbichler, H. Tilg, and J. R. Patsch, “Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro,” Biochemical and Biophysical Research Communications, vol. 309, no. 2, pp. 286–290, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Bokarewa, I. Nagaev, L. Dahlberg, U. Smith, and A. Tarkowski, “Resistin, an adipokine with potent proinflammatory properties,” Journal of Immunology, vol. 174, no. 9, pp. 5789–5795, 2005. View at Google Scholar · View at Scopus
  43. N. Silswal, A. K. Singh, B. Aruna, S. Mukhopadhyay, S. Ghosh, and N. Z. Ehtesham, “Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway,” Biochemical and Biophysical Research Communications, vol. 334, no. 4, pp. 1092–1101, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Verma, S. Li, C. Wang et al., “Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction,” Circulation, vol. 108, no. 6, pp. 736–740, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. W. Hu, S. Qiao, Q. Hou, and J. Yuan, “Plasma resistin is increased in patients with unstable angina,” Chinese Medical Journal, vol. 120, no. 10, pp. 871–875, 2007. View at Google Scholar · View at Scopus
  46. S. E. Lee and H. S. Kim, “Human resistin in cardiovascular disease,” Journal of Smooth Muscle Research, vol. 48, no. 1, pp. 27–35, 2012. View at Google Scholar
  47. Y. Cho, S. Lee, H. Lee et al., “Adipokine resistin is a key player to modulate monocytes, endothelial cells, and smooth muscle cells, leading to progression of atherosclerosis in rabbit carotid artery,” Journal of the American College of Cardiology, vol. 57, no. 1, pp. 99–109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Yaturu, R. D. Reddy, J. Rains, and S. K. Jain, “Plasma and urine levels of resistin and adiponectin in chronic kidney disease,” Cytokine, vol. 37, no. 1, pp. 1–5, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. R. C. Page, “The role of inflammatory mediators in the pathogenesis of periodontal disease,” Journal of Periodontal Research, vol. 26, no. 3, pp. 230–242, 1991. View at Google Scholar · View at Scopus
  50. R. C. Page, “The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm,” Annals of Periodontology, vol. 3, no. 1, pp. 108–120, 1998. View at Google Scholar · View at Scopus
  51. F. A. Scannapieco, “Position paper of The American Academy of Periodontology: periodontal disease as a potential risk factor for systemic diseases,” Journal of Periodontology, vol. 69, no. 7, pp. 841–850, 1998. View at Google Scholar · View at Scopus
  52. T. Saito, N. Yamaguchi, Y. Shimazaki et al., “Serum levels of resistin and adiponectin in women with periodontitis: the hisayama study,” Journal of Dental Research, vol. 87, no. 4, pp. 319–322, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. Y. Hiroshima, M. Bando, Y. Inagaki et al., “Resistin in gingival crevicular fluid and induction of resistin release by Porphyromonas gingivalis lipopolysaccharide in human neutrophils,” Journal of Periodontal Research, vol. 47, no. 5, pp. 554–562, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. G. S. Zimmermann, M. F. Bastos, T. E. Dias Gonçalves, L. Chambrone, and P. M. Duarte, “Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis,” Journal of Periodontology, vol. 84, no. 5, pp. 624–633, 2013. View at Google Scholar