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Disease Markers
Volume 2014, Article ID 947432, 8 pages
http://dx.doi.org/10.1155/2014/947432
Clinical Study

The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T-Cell Recovery and Persistent B-Cell Activation

1School of Pathology and Laboratory Medicine, University of WA, Nedlands, WA 6009, Australia
2Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, WA 6000, Australia
3Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, WA 6000, Australia
4Immunology & Immunopathology, PathWest Laboratory Medicine, Nedlands, WA 6009, Australia
5Medicine and Pharmacology, University of WA, Nedlands, WA 6009, Australia

Received 12 September 2014; Accepted 30 October 2014; Published 23 November 2014

Academic Editor: Giuseppe Murdaca

Copyright © 2014 Samantha J. Brunt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [13 citations]

The following is the list of published articles that have cited the current article.

  • Dino BA Tan, Fathiah S Amran, Teck-Hui Teo, Patricia Price, and Yuben P Moodley, “Levels of CMV-reactive antibodies correlate with the induction of CD28null T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD),” Cellular and Molecular Immunology, 2015. View at Publisher · View at Google Scholar
  • Dino B A Tan, Fathiah S Amran, Teck-Hui Teo, Patricia Price, and Yuben P Moodley, “Levels of CMV-reactive antibodies correlate with the induction of CD28null T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD),” Cellular and Molecular Immunology, vol. 13, no. 4, pp. 551–553, 2015. View at Publisher · View at Google Scholar
  • Viviana Cobos Jiménez, Ferdinand W. N. M. Wit, Maaike Joerink, Irma Maurer, Agnes M. Harskamp, Judith Schouten, Maria Prins, Ester M. M. van Leeuwen, Thijs Booiman, Steven G. Deeks, Peter Reiss, and Neeltje A. Kootstra, “T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment,” Journal of Infectious Diseases, pp. jiw146, 2016. View at Publisher · View at Google Scholar
  • Samantha J. Brunt, Lucette A. Cysique, Silvia Lee, Sally Burrows, Bruce J. Brew, and Patricia Price, “Do Cytomegalovirus Antibody Levels Associate with Age-Related Syndromes in HIV Patients Stable on Antiretroviral Therapy?,” AIDS Research and Human Retroviruses, 2016. View at Publisher · View at Google Scholar
  • Nell S. Lurain, Barbara A. Hanson, Anna L. Hotton, Kathleen M. Weber, Mardge H. Cohen, and Alan L. Landay, “The Association of Human Cytomegalovirus with Biomarkers of Inflammation and Immune Activation in HIV-1-Infected Women,” Aids Research And Human Retroviruses, vol. 32, no. 2, pp. 134–143, 2016. View at Publisher · View at Google Scholar
  • Thijs Booiman, Ferdinand W. Wit, Arginell F. Girigorie, Irma Maurer, Davide De Francesco, Caroline A. Sabin, Agnes M. Harskamp, Maria Prins, Claudio Franceschi, Steven G. Deeks, Alan Winston, Peter Reiss, and Neeltje A. Kootstra, “Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls,” Plos One, vol. 12, no. 8, pp. e0183357, 2017. View at Publisher · View at Google Scholar
  • Anna C. Hearps, Paul A. Agius, Jingling Zhou, Samantha Brunt, Mkunde Chachage, Thomas A. Angelovich, Paul U. Cameron, Michelle Giles, Patricia Price, Julian Elliott, and Anthony Jaworowski, “Persistence of Activated and Adaptive-Like NK Cells in HIV+ Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Eshan U. Patel, Sara Gianella, Kevin Newell, Aaron A.R. Tobian, Allison R. Kirkpatrick, Fredrick Nalugoda, Mary K. Grabowski, Ronald H. Gray, David Serwadda, Thomas C. Quinn, Andrew D. Redd, and Steven J. Reynolds, “Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation,” Aids, vol. 31, no. 6, pp. 807–813, 2017. View at Publisher · View at Google Scholar
  • Shelley Waters, Emily Brook, Silvia Lee, Riwanti Estiasari, Ibnu Ariyanto, and Patricia Price, “HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV,” Clinical Immunology, 2017. View at Publisher · View at Google Scholar
  • Siew Hwei Yap, Noor Kamila Abdullah, Megan McStea, Kozo Takayama, Meng Li Chong, Elisa Crisci, Marie Larsson, Iskandar Azwa, Adeeba Kamarulzaman, Kok Hoong Leong, Yin Ling Woo, and Reena Rajasuriar, “HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution,” Plos One, vol. 12, no. 10, pp. e0186000, 2017. View at Publisher · View at Google Scholar
  • Ibnu A. Ariyanto, Riwanti Estiasari, Shelley Waters, Endah A.T. Wulandari, Sonia Fernandez, Silvia Lee, and Patricia Price, “Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy,” Viral Immunology, 2018. View at Publisher · View at Google Scholar
  • Christine Bundell, Samantha J. Brunt, Lucette A. Cysique, Anna Brusch, Bruce J. Brew, and Patricia Price, “The high frequency of autoantibodies in HIV patients declines on antiretroviral therapy,” Pathology, 2018. View at Publisher · View at Google Scholar
  • Ibnu A Ariyanto, Riwanti Estiasari, Lukman Edwar, Nandini Makwana, Silvia Lee, and Patricia Price, “Characterization of Natural Killer Cells in HIV Patients Beginning Therapy with a High Burden of Cytomegalovirus,” Immunological Investigations, pp. 1–10, 2018. View at Publisher · View at Google Scholar