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Disease Markers
Volume 2015 (2015), Article ID 121848, 7 pages
http://dx.doi.org/10.1155/2015/121848
Research Article

Validation of Serum Biomarkers Derived from Proteomic Analysis for the Early Screening of Preeclampsia

1Department of Medical Genetics, Athens University, “Aghia Sofia” Children’s Hospital, 11527 Athens, Greece
22nd Department of Pediatrics, Athens University, 11527 Athens, Greece
31st Department of Obstetrics & Gynecology, Athens University, 11528 Athens, Greece

Received 8 September 2014; Accepted 27 November 2014

Academic Editor: Irene Rebelo

Copyright © 2015 Aggeliki Kolialexi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Sibai, G. Dekker, and M. Kupferminc, “Pre-eclampsia,” The Lancet, vol. 365, no. 9461, pp. 785–799, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. E. Stekkinger, M. Zandstra, L. L. H. Peeters, and M. E. A. Spaanderman, “Early-onset preeclampsia and the prevalence of postpartum metabolic syndrome,” Obstetrics and Gynecology, vol. 114, no. 5, pp. 1076–1084, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. E. Berzan, R. Doyle, and C. M. Brown, “Treatment of preeclampsia: current approach and future perspective,” Current Hypertension Reports, vol. 16, no. 9, p. 473, 2014. View at Google Scholar
  4. J. L. Maron, K. L. Johnson, D. Slonim et al., “Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood,” The Journal of Clinical Investigation, vol. 117, no. 10, pp. 3007–3019, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. C. Y. T. Ong, A. W. Liao, K. Spencer, S. Munim, and K. H. Nicolaides, “First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein a as predictors of pregnancy complications,” British Journal of Obstetrics and Gynaecology, vol. 107, no. 10, pp. 1265–1270, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Pilalis, A. P. Souka, P. Antsaklis et al., “Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks' gestation,” Ultrasound in Obstetrics and Gynecology, vol. 29, no. 2, pp. 135–140, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. L. C. Y. Poon, N. A. Kametas, N. Maiz, R. Akolekar, and K. H. Nicolaides, “First-trimester prediction of hypertensive disorders in pregnancy,” Hypertension, vol. 53, no. 5, pp. 812–818, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. S. Sifakis, R. Akolekar, D. Kappou, N. Mantas, and K. H. Nicolaides, “Maternal serum insulin-like growth factor-binding protein-3 (IGFBP-3) at 11–13 weeks in preeclampsia,” Journal of Human Hypertension, vol. 26, no. 4, pp. 253–258, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. S. Sifakis, R. Akolekar, N. Mantas, D. Kappou, and K. H. Nicolaides, “Maternal serum human placental growth hormone (hPGH) at 11 to 13 weeks of gestation in preeclampsia,” Hypertension in Pregnancy, vol. 30, no. 1, pp. 74–82, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. K. Spencer, N. J. Cowans, and A. Stamatopoulou, “ADAM12s in maternal serum as a potential marker of pre-eclampsia,” Prenatal Diagnosis, vol. 28, no. 3, pp. 212–216, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. D. M. Carty, E. Schiffer, and C. Delles, “Proteomics in hypertension,” Journal of Human Hypertension, vol. 27, no. 4, pp. 211–216, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. J. Klein, B. Buffin-Meyer, W. Mullen et al., “Clinical proteomics in obstetrics and neonatology,” Expert Review of Proteomics, vol. 11, no. 1, pp. 75–89, 2014. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. A. Kolialexi, A. Mavrou, G. Spyrou, and G. T. Tsangaris, “Mass spectrometry-based proteomics in reproductive medicine,” Mass Spectrometry Reviews, vol. 27, no. 6, pp. 624–634, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. V. Kolla, P. Jenö, S. Moes, O. Lapaire, I. Hoesli, and S. Hahn, “Quantitative proteomic (iTRAQ) analysis of 1st trimester maternal plasma samples in pregnancies at risk for preeclampsia,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 305964, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Blumenstein, M. T. McMaster, M. A. Black et al., “A proteomic approach identifies early pregnancy biomarkers for preeclampsia: novel linkages between a predisposition to preeclampsia and cardiovascular disease,” Proteomics, vol. 9, no. 11, pp. 2929–2945, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. J. Rasanen, A. Girsen, X. Lu et al., “Comprehensive maternal serum proteomic profiles of preclinical and clinical preeclampsia,” Journal of Proteome Research, vol. 9, no. 8, pp. 4274–4281, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. N. Papantoniou, V. Bagiokos, K. Agiannitopoulos et al., “RASSF1A in maternal plasma as a molecular marker of preeclampsia,” Prenatal Diagnosis, vol. 33, no. 7, pp. 682–687, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. F. Lyall, R. G. Hayman, J. R. Ashworth, E. Duffie, and P. N. Baker, “Relationship of cell adhesion molecule expression to endothelium-dependent relaxation in normal pregnancy and pregnancies complicated with preeclampsia or fetal growth restriction,” Journal of the Society for Gynecologic Investigation, vol. 6, no. 4, pp. 196–201, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Krauss, W. Kuhn, C. Lakoma, and H. G. Augustin, “Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia,” The American Journal of Obstetrics and Gynecology, vol. 177, no. 2, pp. 443–449, 1997. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Haller, E.-M. Ziegler, V. Homuth et al., “Endothelial adhesion molecules and leukocyte integrins in preeclamptic patients,” Hypertension, vol. 29, no. 1, part 2, pp. 291–296, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Spencer, N. J. Cowans, and K. H. Nicolaides, “Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia,” Prenatal Diagnosis, vol. 28, no. 1, pp. 7–10, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. J. F. Carbone, M. G. Tuuli, R. Bradshaw, J. Liebsch, and A. O. Odibo, “Efficiency of first-trimester growth restriction and low pregnancy-associated plasma protein-A in predicting small for gestational age at delivery,” Prenatal Diagnosis, vol. 32, no. 8, pp. 724–729, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. A. O. Odibo, A. Francis, A. G. Cahill, G. A. MacOnes, J. P. Crane, and J. Gardosi, “Association between pregnancy complications and small-for-gestational-age birth weight defined by customized fetal growth standard versus a population-based standard,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 24, no. 3, pp. 411–417, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. J. K. Ranta, K. Raatikainen, J. Romppanen, K. Pulkki, and S. Heinonen, “Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 157, no. 1, pp. 48–52, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. N. Franceschini, C. Qiu, D. A. Barrow, and M. A. Williams, “Cystatin C and preeclampsia: a case control study,” Renal Failure, vol. 30, no. 1, pp. 89–95, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. B. Thilaganathan, B. Wormald, C. Zanardini, J. Sheldon, E. Ralph, and A. T. Papageorghiou, “Early-pregnancy multiple serum markers and second-trimester uterine artery doppler in predicting preeclampsia,” Obstetrics and Gynecology, vol. 115, no. 6, pp. 1233–1238, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. S. Chandrasekaran, L. D. Levine, C. P. Durnwald, M. A. Elovitz, and S. K. Srinivas, “Excessive weight gain and hypertensive disorders of pregnancy in the obese patient,” Journal of Maternal-Fetal and Neonatal Medicine, 2014. View at Publisher · View at Google Scholar · View at PubMed
  28. M. Lucovnik, I. Blickstein, I. Verdenik, L. Steblovnik, A. T. Bregar, and N. Tul, “Impact of pre-gravid body mass index and body mass index change on preeclampsia and gestational diabetes in singleton and twin pregnancies,” The Journal of Maternal-Fetal & Neonatal Medicine, vol. 27, no. 18, pp. 1901–1904, 2014. View at Google Scholar
  29. V. L. Bilano, E. Ota, T. Ganchimeg, R. Mori, and J. P. Souza, “Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low- and middle-income countries: a WHO secondary analysis,” PLoS ONE, vol. 9, no. 3, Article ID e91198, 2014. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus