Research Article

Is It Possible to Differentiate Chronic Kidney Disease and Preeclampsia by means of New and Old Biomarkers? A Prospective Study

Table 1

Main baseline data in the study group.

Data at referral or at 1st test (median; min–max or %)CKD
(: 35)
PE
(: 24)
Other
(: 17)
Statistical significance

Age (yrs)32 (19–41)36.5 (19–54)36 (28–46)
Nulliparous (%)71.4%75.0%47.1%
BMI22.6 (14.8–42.9)24.9 (14.5–36.0)27.3 (17.6–43.9)
Caucasians (%)91.4%95.8%70.6%
Week of test30 (21–39)32 (26–36)34 (25–39)
Hypertension (%)34.3%100%100%
Proteinuria g/day 0.45 (0.04–3.4)0.84 (0.3–16.2)0.23 (0.06–3.7)
Proteinuria <0.3 (%)40%64.7%
≥0.3–<0.5 g/day (%)14.3%29.2%11.8%
0.5–1 g/day (%)11.4%25.0%11.8%
1–3 g/day (%)28.6%29.2%5.9%
≥3 g/day (%)5.7%16.7%5.9%
s-Creatinine (mg/dL)0.60 (0.38–2.59)0.67 (0.44–0.99)0.57 (0.34–0.83)
GFR (mL/min)119 (23–147)115 (48–144)124 (91–138)

CKD: chronic kidney disease; PE: preeclampsia; BMI: body mass index; GFR: glomerular filtration rate (by CKD-EPI formula); : significance across groups; : CKD versus PE; : CKD versus Other; : PE versus Other. Significance between groups: maternal age: ; ; ; hypertension: ; ; proteinuria: ; ; ; proteinuria (%): ; ; .
Note. Causes of CKD: glomerular 11; interstitial 13; single kidney 3; diabetic nephropathy 3; Other 5. Other diseases (differential diagnosis with PE) included pregnancy-induced hypertension (6 cases); intrauterine growth restriction with or without hypertension (4); chronic hypertension (6 cases); HELLP syndrome after delivery (1 case).