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Disease Markers
Volume 2015, Article ID 128653, 5 pages
Research Article

α-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus

1Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile
2Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile
3Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile
4Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile

Received 9 December 2014; Revised 9 February 2015; Accepted 9 February 2015

Academic Editor: Donald H. Chace

Copyright © 2015 Juan Pablo Aitken et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients. Methods. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between α-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated. Results. We found a positive correlation between α-2-macroglobulin and HbA1c ( and ). Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847–0.959, ) to diagnose glycemic control. Conclusions. Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.