Matrix Metalloproteinase-9/Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis

Figure 2

MMP-9, MMP-9/NGAL, and MMP-9D activity is reduced after tumor removal and recovered after tumor relapse. (a) Gelatin zymography analysis of urine samples from a representative subject who has experienced tumor relapse six months after surgery. (b–d) MRI analysis of the tumor (arrow) from the corresponding patient prior to surgery (b), after surgery (c), and at diagnosis of relapse (d) (AT: adjacent nontumor tissue, TT: tumor tissue, and Preop-1d, Postop-1w, and Post-r urine: fresh urine samples were collected in the morning one day prior to surgery, one week after surgery, and on the day of tumor recurrence diagnosis).

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