Effect of Extended-Release Niacin/Laropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia

Table 2

Changes in body weight and blood biochemical parameters in patients with weight gain and weight loss.

Parameters	Weight gain ()	Weight loss ()
Weight changes (kg)	1.0 ± 0.8	−1.4 ± 1.0	<0.001
% changes in body weight	1.4 ± 1.2	−1.8 ± 1.3	<0.001
% changes in adiponectin	165.6 ± 133.7	171.2 ± 98.7	0.327
% changes in fasting glucose	14.6 ± 13.3	6.7 ± 12.2	0.001
% changes in HbA1c	5.2 ± 5.4	4.7 ± 8.3	0.205
% changes in insulin	80.7 ± 58.1	64.6 ± 104.3	0.007
% changes in HOMA-IR	109.3 ± 82.3	76.3 ± 112.5	0.001
% changes in FFA	150.9 ± 72.0	87.1 ± 117.8	0.201
% changes in total cholesterol	−16.0 ± 14.6	−13.6 ± 14.9	0.403
% changes in HDL-C	20.4 ± 23.4	24.9 ± 22.3	0.336
% changes in triglycerides	−31.1 ± 36.6	−32.2 ± 24.6	0.533
% changes in LDL-C	−21.0 ± 24.1	−19.2 ± 27.4	0.909

FFA: free fatty acids; HbA1c: glycated haemoglobin; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: Homeostasis Model of Assessment-Insulin Resistance; LDL-C: low-density lipoprotein cholesterol.