Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress
Table 8
Predictors of combined end-point (mortality or EF <40% at one year).
Predictors
Univariate
P value*
Multivariate without PTX3
P value*
Multivariate with PTX3
P value*
OR (95% CI)
OR (95% CI)
OR (95% CI)
PTX3 >2.1 ng/mL
8.304 (3.364; 20.498)
<0.001
3.700 (1.332; 10.279)
0.012
Troponin I (max) >90 pg/mL
6.241 (3.102; 12.556)
<0.001
4.329 (1.966; 9.531)
<0.001
3.321 (1.461; 7.549)
0.004
BNP >500 pg/mL
8.361 (4.104; 17.033)
<0.001
6.777 (3.068; 14.970)
<0.001
4.990 (2.196; 11.340)
<0.001
Women
1.125 (0.558; 2.267)
0.743
Age
1.035 (0.998; 1.072)
0.063
BMI
1.057 (0.980; 1.140)
0.151
Systolic BP
0.991 (0.979; 1.003)
0.158
Heart rate
1.027 (1.008; 1.046)
0.005
1.029 (1.007; 1.052)
0.009
1.030 (1.008; 1.054)
0.008
Glycaemia at entry
1.124 (1.044; 1.211)
0.002
Creatinine at entry
1.024 (1.011; 1.037)
<0.001
Diabetes mellitus
3.019 (1.531; 5.952)
0.001
Hypertension
2.644 (1.241; 5.634)
0.012
Dyslipoproteinemia
1.033 (0.425; 2.509)
0.943
History of MI/PCI/CABG
2.745 (1.253; 6.013)
0.012
Pain onset-balloon time
0.994 (0.976; 1.013)
0.543
IRA-LAD/left main
2.090 (1.079; 4.050)
0.029
Three vessels diseases
2.183 (1.408; 3.383)
<0.001
2.079 (1.230; 3.514)
0.006
1.985 (1.159; 3.398)
0.012
Reclassification
Rec. value (95% CI)
P valuea
cfNRI IDI
Reclassification analysis computed for multivariate model containing PTX3 against model without PTX3
0.882 (0.637; 1.126) 0.028 (0.006; 0.051)
<0.001 0.014
Based on logistic regression. aBased on reclassification analysis (cfNRI, IDI). PTX3: pentraxin-3 at 24 h after onset of myocardial infarction; BNP: B-type natriuretic peptide at 24 h after onset of myocardial infarction; BMI: body mass index; BP: blood pressure; MI: myocardial infarction; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting; IRA: infarct related artery; LAD: left anterior descending.
