Characterization of Clinical and Genetic Risk Factors Associated with Dyslipidemia after Kidney Transplantation

Table 3

Association of pharmacokinetics, cytokines, and dyslipidemia-related polymorphisms.

Number	Gene	Polymorphisms	Categories	OR	95% CI
1	IL-2	T-330G	G allele	0.482	0.157–1.480	0.200
2	IL-2R	C-627T	T allele	0.591	0.187–1.867	0.545
3	IL-4	C-590T	TT genotype	0.952	0.316–2.873	0.931
4	IL-10	A-592C	C allele	0.912	0.299–2.784	0.872
5	IL-12B	A1188C	C allele	1.156	0.272–4.905	0.861
6	TNF-	G-238A	A allele	—	—	1.000
		G-308A	A allele	—	—	1.000
7	INF	A874T	T allele	—	—	1.000
8	TGF-1	Codon 10 T/C	CC genotype	1.225	0.322–4.667	0.964
		Codon 25 G/C	C allele	—	—	1.000
		C-509T	TT genotype	0.719	0.203–2.543	0.844
9	CRP	T-717C	C allele	1.474	0.268–8.092	0.993
		G1059C	C allele	2.289	0.349–15.010	0.686
		C1444T	T allele	0.926	0.228–3.765	0.804
		C1846T	TT genotype	1.067	0.358–3.182	0.908
10	HNF1	Ileu27Leu	Leu/Leu genotype	0.857	0.318–2.310	0.760
		Ala98Val	Val allele	—	—	1.000
11	Adiponectin	T45G	G allele	2.000	0.659–6.066	0.341
		G276T	T allele	0.889	0.236–3.351	0.869
12	PPAR	Val227Ala	Ala allele	—	—	1.000
13	PPAR	Pro12Ala	Ala allele	2.000	0.115–34.824	0.866
		C161T	T allele	2.036	0.518–7.995	0.565
14	PPAR coactivator1	Gly482Ser	Ser/ser genotype	3.250	0.480–21.998	0.438
		G394A	A allele	0.381	0.073–1.992	0.449
15	Clock gene	T3111C	C allele	—	—	0.876
16	ACE	I/D	Deletion	1.270	0.381–4.230	0.697
17	ATIIR	A1166C	C allele	0.454	0.105–1.955	0.464
18	KCNJ11	E23K	A allele	0.571	0.185–1.765	0.329
19	SUR1	C-3T	TT genotype	0.286	0.081–1.008	0.946
20	UGT1A1	Promoter TA-repeat	^*6 allele	0.729	0.299–1.777	0.486
21	UGT1A6^*2	^*1/^*2	^*2 allele	0.955	0.255–3.576	0.789
22	UGT1A7	Codon 208^* 1/^*3	^*3 allele	1.280	0.228–7.187	0.873
23	UGT1A8^*2	codon173 A/G	GG genotype	1.176	0.507–2.732	0.705
24	UGT1A8^*3	codon277 C/Y	Y allele	—	—	1.000
25	UGT1A9						C-2152T	T allele	—	—	1.000
		T-275A	A allele	—	—	1.000
		C1399T	TT genotype	1.126	0.485–2.617	0.783
26	UGT1A9^*3	T98C	C allele	—	—	1.000
27	UGT2B7	C802T	T allele	0.770	0.330–1.795	0.545
28	CYP2C9^*2	C430T	T allele	—	—	1.000
29	CYP2C9^*3	A1075C	C allele	2.741	0.715–10.509	0.242
30	CYP2C19	^*1/^*2/^*3	^*2/^*2, ^*2/^*3, ^*3/^*3	0.697	0.220–2.208	0.739
31	CYP3A4	^*1/^*18	^*18 allele	—	—	1.000
		G20230A	A allele	0.551	0.235–1.294	0.169
32	CYP3A5	A6985G	GG genotype	1.815	0.773–4.263	0.169
33	MDR-1	C1236T	TT genotype	1.067	0.291–3.916	0.814
		C3435T	T allele	0.868	0.200–3.766	0.850
		G2677T·A	T or A allele	0.688	0.152–3.102	0.922
34	OATP1B1	A388G	GG genotype	1.143	0.482–2.712	0.762
		G455A	A allele	—	—	1.000
		T521C	C allele	0.593	0.226–1.551	0.284
		G721A	A allele	—	—	1.000
35	OATP1B3	T334G	GG genotype	1.176	0.507–2.732	0.705
		G699A	AA genotype	0.714	0.242–2.108	0.542
		Deletion A	Deletion	1.309	0.310–5.534	0.714
36	OATP2B1	^*1/^*3	^*3 allele	0.936	0.402–2.176	0.877
37	Glucocorticoid receptor	Bcl I C/G	G allele	3.375	1.568–7.266	0.001
		ER22/23EK	EK allele	—	—	1.000
		N363S	S allele	—	—	1.000
38	CES2	rs2303218	AA genotype	2.700	0.697–10.465	0.146
		rs3890213	A allele	3.429	0.791–14.854	0.190

IL, interleukin; TNF, tumor necrosis factor; INF, interferon; TGF, transforming growth factor; CRP, C-reactive protein; HNF, hepatocyte nuclear factor; PPAR, peroxisome proliferator-activated receptor; ACE, angiotensin-converting enzyme; ATIIR, angiotensin type 2 receptor; KCNJ, potassium inwardly rectifying channel, subfamily J; SUR, sulfonylurea receptor; UGT, uridine diphosphate-glucuronosyltransferase; CYP, cytochrome P450; MDR, multidrug resistance; OATP, organic anion transporting polypeptide; CES, carboxylesterase; OR, odds ratio; CI, confidence interval.