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Research Article

CYP7A1 Gene Polymorphism Located in the 5′ Upstream Region Modifies the Risk of Coronary Artery Disease

Table 2

Distribution of the genotypes and alleles of the rs7833904 polymorphism in the group of coronary artery disease (CAD) patients and controls.

Genotype/alleleCAD
Control
ModelOR (CI 95%),
(%) (%)

TT45 (22.50%)74 (33.78%)Additive1
AT98 (49.00%)101 (46.12%)1.59 (1.00–2.53) 0.06
AA57 (28.50%)44 (20.10%)2.13 (1.24–3.66), 0.008*
AA + AT
TT
155 (77.50%)
45 (22.50%)
145 (66.21%)
74 (33.78%)
Dominant1.76 (1.14–2.71), 0.014*
1
AT + TT
AA
143 (71.50%)
57 (28.50%)
175 (79.90%)
44 (20.10%)
Recessive0.63 (0.40–0.99), 0.058
1

A212 (53.00%)189 (43.15%)1.49 (1.13–1.95), 0.005* vs T
T188 (47.00%)249 (56.85%)0.67 (0.51–0.88), 0.005* vs A

*—statistically significant differences between groups.

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