Research Article
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis
Table 1
Methylation/deletion frequencies for 50 NotI-sites (gene/locus) with the highest percent of changes in prostate adenoma and cancer.
| | No | NotI-site | Gene/locus | Localization | Methylation/deletion frequency | | Adenoma | Cancer () | Cancer () |
| | 1 | NR5-IH18RS | BHLHE40 | 3p26.1 | 80% (14/15) | 79% (11/14) | 100% (4/4) | | 2 | NR1-XM13C | IQSEC1 | 3p25.2 | 73% (11/15) | 79% (11/14) | 100% (4/4) | | 3 | NR1-AK24R | BCL6 | 3q27 | 73% (11/15) | 79% (11/14) | 100% (4/4) | | 4 | NL1-BA6R | FOXP1 | 3p14.1 | 67% (10/15) | 79% (11/14) | 100% (4/4) | | 5 | NR1-KJ5R (C) | FBLN2 | 3p25.1 | 73% (11/15) | 64% (9/14) | 100% (4/4) | | 6 | NR1-EP7RS | CLASP2 | 3p22.3 | 80% (12/15) | 57% (8/14) | 100% (4/4) | | 7 | NL1Z216R (D) | MANF | 3p21.1 | 80% (12/15) | 64% (9/14) | 75% (3/4) | | 8 | NL1-GK21R (C) | ROPN1/KALRN | 3q13.3 | 60% (9/15) | 79% (11/14) | 100% (4/4) | | 9 | NL4-AP18R (C) | PLCL2 | 3p24.3 | 53% (8/15) | 86% (12/14) | 75% (3/4) | | 10 | NL1A401R (D) | ITGA9 | 3p21.3 | 60% (9/15) | 71% (10/14) | 100% (4/4) | | 11 | NLJ-003RD | CTDSPL (RBSP3) | 3p21.3 | 73% (11/15) | 64% (9/14) | 75% (3/4) | | 12 | NL3003R (U) | GORASP1/TTC21A | 3p22-p21.33 | 67% (10/15) | 71% (10/14) | 75% (3/4) | | 13 | NL3-CI2R (C) | LOC285205 | 3q13.12 | 73% (11/15) | 57% (8/14) | 100% (4/4) | | 14 | NR5-FG18R (C) | FSTL1 | 3q13.33 | 73% (11/15) | 57% (8/14) | 100% (4/4) | | 15 | NR1-WD21R (C) | NEK11/NUDT16 | 3q22.1 | 60% (9/15) | 64% (9/14) | 100% (4/4) | | 16 | NL3A001R (D) | GNAI2 | 3p21.31 | 53% (8/15) | 64% (9/14) | 100% (4/4) | | 17 | NR1-AN24RS | ABHD5/C3orf77 | 3p21 | 53% (8/15) | 71% (10/14) | 50% (2/4) | | 18 | NR1-PD1R | ZIC4 | 3q24 | 47% (7/15) | 64% (9/14) | 100% (4/4) | | 19 | NL1-VJ14R (C) | LOC285375 | 3p25.1 | 60% (9/15) | 43% (6/14) | 100% (4/4) | | 20 | NL4-BC8R (C) | ALDH1L1 | 3q21.3 | 33% (5/15) | 79% (11/14) | 75% (3/4) | | 21 | NL1-YJ5R (C) | С3orf46/CHCHD6 | 3q21.3 | 60% (9/15) | 50% (7/14) | 75% (3/4) | | 22 | NL1-GC10C | HMGB1L5 (Pseudo) | 3p24 | 67% (10/15) | 43% (6/14) | 50% (2/4) | | 23 | NR5-FK16RS | MINA | 3q11.2 | 40% (6/15) | 57% (8/14) | 100% (4/4) | | 24 | NL1-FK10R (C) | PPP2R3A | 3q22.1 | 33% (5/15) | 64% (9/14) | 100% (4/4) | | 25 | NL1-ZD4R | SOX2 | 3q26.3-q27 | 40% (6/15) | 57% (8/14) | 100% (4/4) | | 26 | NR1-NH1R (C) | FGF12 | 3q28 | 53% (8/15) | 64% (9/14) | 25% (1/4) | | 27 | NR5-FK11R (C) | CMTM8 | 3p22.3 | 67% (10/15) | 50% (7/14) | 0% (0/4) | | 28 | NL4-BH3R (C) | GATA2 | 3q21.3 | 20% (3/15) | 71% (10/14) | 100% (4/4) | | 29 | NL4-BK12R (C) | WNT7A | 3p25 | 40% (6/15) | 43% (6/14) | 100% (4/4) | | 30 | NR1-WD23R (C) | LRRC58 | 3q13.33 | 53% (8/15) | 29% (4/14) | 100% (4/4) | | 31 | NL4-BI4RS | RAP2B | 3q25.2 | 47% (7/15) | 57% (8/14) | 25% (1/4) | | 32 | NL1-ZP13R (C) | KBTBD8 | 3p14 | 47% (7/15) | 50% (7/14) | 25% (1/4) | | 33 | NR1-WE11RS | CGGBP1 | 3p12-p11.1 | 33% (5/15) | 43% (6/14) | 100% (4/4) | | 34 | HSJ4-AB7R (C) | RPL32/IQSEC1 | 3p25.2 | 27% (4/15) | 43% (6/14) | 100% (4/4) | | 35 | NL4-DP2RS | FGD5 | 3p25.1 | 33% (5/15) | 36% (5/14) | 100% (4/4) | | 36 | NL1-CJ4R (C) | NKIRAS1/RPL15 | 3p24.2 | 40% (6/15) | 50% (7/14) | 25% (1/4) | | 37 | NL6-II3R | USP19 | 3p21.31 | 27% (4/15) | 43% (6/14) | 100% (4/4) | | 38 | NL1268R (P65D) | TMEM45A | 3q12.2 | 27% (4/15) | 50% (7/14) | 75% (3/4) | | 39 | NR1-WJ2RS | SOX14 | 3q22-q23 | 27% (4/15) | 57% (8/14) | 50% (2/4) | | 40 | NL1-VC9R (C) | GPR149 | 3q25.2 | 47% (7/15) | 43% (6/14) | 25% (1/4) | | 41 | NR1-WH9R (C) | RRP9/PARP3 | 3p21.2 | 47% (7/15) | 29% (4/14) | 50% (2/4) | | 42 | NR1-NC7RS | PPM1M | 3p21.2 | 40% (6/15) | 43% (6/14) | 25% (1/4) | | 43 | NR5-IG2R (C) | KY | 3q22.2 | 60% (9/15) | 14% (2/14) | 50% (2/4) | | 44 | NR1-WL7R (C) | DZIP1L | 3q22.3 | 53% (8/15) | 36% (5/14) | 0% (0/4) | | 45 | NR1-NM7R (C) | B3GALNT1 | 3q25 | 27% (4/15) | 43% (6/14) | 75% (3/4) | | 46 | NL3-CA11RS | LRRC3B | 3p24 | 27% (4/15) | 29% (4/14) | 100% (4/4) | | 47 | NL6-AF21R (C) | PDZRN3 | 3p13 | 40% (6/15) | 29% (4/14) | 50% (2/4) | | 48 | NL1A079R (D) | EPHB1 | 3q21-q23 | 27% (4/15) | 36% (5/14) | 75% (3/4) | | 49 | NL3A006R (D) | NBEAL2 | 3p21.31 | 20% (3/15) | 36% (5/14) | 75% (3/4) | | 50 | NR1-WB21R (C) | EPHB3 | 3q21-qter | 40% (6/15) | 36% (5/14) | 0% (0/4) |
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Note. : Gleason grading system score.
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