Research Article

Overexpression of FRAT1 Is Associated with Malignant Phenotype and Poor Prognosis in Human Gliomas

Table 1

Measurements of FRAT1 IRS, Pi, Ii, and MVD in gliomas.

Glioma tissuesFRAT1 IRSPi %Ii %MVD

Grade I101.30 ± 1.7712.62 ± 11.249.18 ± 12.0330.36 ± 11.69
Grade II192.63 ± 2.9123.66 ± 13.6919.84 ± 15.6651.08 ± 15.27
Grade III164.50 ± 3.7635.19 ± 16.0826.80 ± 18.0573.81 ± 24.52
Grade IV236.70 ± 3.8948.23 ± 21.0539.91 ± 19.1290.14 ± 29.28

Total684.25 ± 3.86a33.06 ± 20.93a26.70 ± 19.93a66.59 ± 31.05a

as compared among Grades I to IV of brain gliomas (by ANOVA). IRS, immunoreactivity score; Pi, proliferative index; Ii, invasive index; MVD, microvessel density.