Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection

Table 2

Comparison of clinicopathological factors according to postopCA19-9 (normalized postopCA19-9 versus persistently elevated postopCA19-9) in patients with elevated preopCA19-9^† ().

Factors	Normalized postopCA19-9; ()	Persistently elevated postopCA19-9; ()	value
Age (>65/≤65 years)	23/11	7/4	0.31
Sex (male/female)	23/11	6/5	0.353
Viral hepatitis B (yes/no)	3/31	2/9	0.355
Tumor size (>5/≤5 cm)	24/10	7/4	0.49
Major vascular invasion (yes/no)	5/29	2/9	0.443
Microvascular invasion (yes/no)	12/22	8/3	0.034
Perineural invasion (yes/no)	10/24	7/4	0.048
Lymphatic invasion (yes/no)	14/20	8/3	0.07
Intrahepatic metastasis (yes/no)	9/25	5/6	0.208
T stage, AJCC 6th (I, II/III, IV)	19/15	4/6	0.3
Lymph node metastasis (yes/no)	10/24	5/6	0.266
Adjuvant therapy (yes/no)	9/25	2/9	0.454
Resection margin (>1/≤1 cm)	23/11	7/4	0.565

PreopCA19-9^†: preoperative CA19-9; postopCA19-9: postoperative lowest CA19-9.