Overexpression of Growth-Related Oncogene-β Is Associated with Tumorigenesis, Metastasis, and Poor Prognosis in Ovarian Cancer

Table 2

Univariate and multivariate analysis of prognostic factors for 5-year survival in ovarian cancer.

	Univariate analysis				Multivariate analysis
	HR		95% CI		HR		95% CI
GRO-β expression
High versus low	4.450	<	2.495	7.937	3.789		1.659	8.655
Age (years)
≤60 versus >60	1.733		1.060	2.832	1.693	0.163	0.807	3.554
Histological type
Serous versus endometrioid versus others	0.768		0.618	0.954	0.846	0.191	0.660	1.086
Differentiation
Low versus High	0.496	0.117	0.206	1.192
Ascites
No versus Yes	1.659	0.079	0.942	2.919
Lymph node and other metastases
No versus Yes	3.425	<	1.966	5.965	0.737	0.600	0.236	2.301
FIGO stage
I~II versus III versus IV	1.962	<	1.511	2.547	3.900	0.119	0.703	3.616
CEA level
≤5 versus >5	0.823	0.657	0.349	1.941
CA199 level
≤37 versus >37	0.241		0.086	0.675	0.184		0.060	0.568
CA125 level
≤35 versus >35	1.826	0.249	0.655	5.089
CA153 level
≤31 versus >31	2.130		1.122	4.045	1.146	0.755	0.487	2.695
SF level
≤204 versus >204	1.476	0.213	0.799	2.725

.
Others: clear cell, nine cases; mucinous, seven cases; transitional cell, six cases; mixed, 12 cases.