Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease

Table 2

The mean, standard deviation, and range of the laboratory data in the case and control groups and value of comparing these data between case and control groups.

	MAS	Control (active disease)	p value
WBC1 (×10^3/uL)	16122 ± 9105 (6100–38121)	16280 ± 10857 (2520–61300)	1
WBC2 (×10^3/uL)	8784 ± 10310 (520–38430)	15679 ± 8502 (700–41200)	0.001
WBC3 (×10^3/uL)	15617 ± 12602 (1130–46670)	10299 ± 4551 (2140–25500)	0.2
PMN1 (×10^3/uL)	11664 ± 8500 (1449–34080)	11174 ± 7870 (1128–36556)	0.4
PMN2 (×10^3/uL)	6775 ± 6569 (120–18069)	11377 ± 7536 (583–35020)	0.02
PMN3 (×10^3/uL)	11472 ± 9539 (1142–31408)	5834 ± 3462 (1001–17110)	0.07
Lymph1 (×10^3/uL)	4046 ± 4477 (866–19500)	3815 ± 4441 (1108–32550)	0.9
Lymph2 (×10^3/uL)	2638 ± 3731 (639–15333)	3635 ± 1812 (1209–8694)	<0.001
Lymph3 (×10^3/uL)	3356 ± 2600 (550–8390)	3501 ± 1917 (107–11272)	0.4
Hgb1 (g/dL)	9.13 ± 1.45 (6.80–12.20)	10.40 ± 1.40 (7.50–14.3)	0.003
Hgb2 (g/dL)	7.96 ± 1.66 (6.10–11.4)	10.33 ± 1.66 (7.30–14.5)	<0.001
Hgb3 (g/dL)	8.95 ± 1.16 (6.90–10.70)	11.58 ± 1.91 (6.50–15)	<0.001
PLT1 (/microliter)	292588 ± 170526 (29000–638000)	489365 ± 212249 (138000–1144000)	0.001
PLT2 (/microliter)	105882 ± 91791 (9000–406000)	502617 ± 189080 (56000–1010000)	<0.001
PLT3 (/microliter)	321785 ± 177361 (44000–770000)	393512 ± 143221 (68000–779000)	0.07
ESR1 (mm/h)	69.53 ± 40.96 (9–126)	73.67 ± 30.24 (5–125)	0.7
ESR2 (mm/h)	46.81 ± 49.47 (2–165)	72.21 ± 35.82 (6–148)	0.008
ESR3 (mm/h)	37.53 ± 30.176 (10–102)	23.78 ± 27.85 (3–140)	0.1
CRP1 (mg/L)	37 ± 23.61 (5–75)	68 ± 52 (0–246)	0.3
CRP2 (mg/L)	139 ± 101 (40–345)	96 ± 70 (22–317)	0.1
CRP3 (mg/L)	32.84 ± 46 (0.5–168)	14.91 ± 19.4 (0–75)	0.03
ALT (u/L)	315 ± 840 (12–3560)	28.28 ± 31.4 (6–187)	<0.001
AST (u/L)	583 ± 1506 (17–6300)	32.2 ± 21.7 (10–142)	<0.001
ALP (u/L)	409 ± 290 (165–1220)	392 ± 171 (84–941)	0.3
ALB (gr/dL)	3.03 ± 0.69 (2–4.3)	3.80 ± 0.62 (2.7–4.7)	0.002
Total Pr (gr/dL)	6.42 ± 1.77 (4–8.7)	6.90 ± 1.04 (4.9–8.4)	0.5
BilT (mg/dL)	5.36 ± 7.72 (0.4–24.3)	0.88 ± 0.91 (0.4–2.7)	0.050
BilD (mg/dL)	3.32 ± 4.87 (0.1–14)	0.26 ± 0.16 (0.2–0.6)	0.2
Ferritin (ng/mL)	60590 ± 73343 (1617–200000)	5253 ± 5505 (300–18035)	0.009
Fibrinogen (mg/dL)	517 ± 641 (130–4944)	489 ± 94 (423–556)	0.2
LDH (Iu/L)	1913 ± 1516 (136–4944)	679 ± 336 (258–1318)	0.02
BUN (mg/dL)	16.75 ± 11.94 (5–41)	10.18 ± 4.03 (4–26)	0.1
Cr (mg/dL)	0.60 ± 0.39 (0.12–1.80)	0.55 ± 0.11 (0.3–0.8)	0.5
Na (meq/L)	130 ± 6.3 (115–137)	136 ± 4.3 (128–144)	0.004
TG (mg/dL)	329 ± 188 (109–727)	161 ± 119 (42–280)	0.1
Chol (mg/dL)	224 ± 130 (112–530)	181 ± 131 (88–274)	0.7
PT	18.06 ± 7.7 (13–43)	16.4 ± 7.9 (12–34)	0.04
PTT	43 ± 14 (18–75)	31.50 ± 9.44 (13–45)	0.006
INR	1.67 ± 0.6 (1–2.7)	1.16 ± 0.26 (1–1.8)	0.009

MAS: Macrophage Activation Syndrome, WBC: white blood cells, PMN: polymorphonuclear, Lymph: lymphocytes, Hgb: hemoglobin, PLT: platelet, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, ALB: albumin, Total Pr: total protein, Bil T: total bilirubin, Bil D: direct bilirubin, LDH: lactate dehydrogenase, BUN: blood urea nitrogen, Cr: creatinine, Na: natrium, TG: triglycerides, Chol: cholesterol, PT: prothrombin time, PTT: partial prothrombin time, and INR: international normalized ratio. The previous laboratory records: WBC1, PMN1, and so forth. The laboratory data at the onset of MAS (MAS group) or active rheumatologic disease (control group): WBC2, PMN2, and so forth. The laboratory data 1 month after discharge from the hospital: WBC3, PMN3, and so forth.