Disease Markers

Research Article

Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease

Table 3

Differences between parameters detected at 2 different times in the case and control groups and value of comparing data between these two groups. The values are reported as mean ± standard deviation (range).
ParameterMASControl value
WBC1-WBC2 (×103/uL)7337 ± 11572 (−19030 to 34191)781.04 ± 9243 (−24000 to 43500)0.004
WBC3-WBC2 (×103/uL)8284 ± 14647 (−19640 to 44070)−5593 ± 7941 (−28800 to 9830)0.00
PMN1-PMN2 (×103/uL)4888–10049 (−16228 to 31407)−137 ± 6127 (−16908 to 12555)0.02
PMN3-PMN2 (×103/uL)6404 ± 9787 (−3750 to 29622)−6167 ± 6288 (−21261 to 3572)<0.001
Lymph1-Lymph2 (×103/uL)1277 ± 5889 (−11763 to 17670)381.78 ± 4864 (−6972 to 28278)0.07
Lymph3-Lymph2 (×103/uL)1484 ± 2505 (−1151 to 6560)135.45 ± 2504 (−6927 to 8025)0.1
Hgb1-Hgb2 (g/dL)1.24 ± 1.34 (−1.10 to 4.20) 0.067 ± 1.38 (−2.50 to 2.90)0.008
Hgb3-Hgb2 (g/dL)1.17 ± 1.45 (−1.50 to 3.10)1.17 ± 1.75 (−2.40 to 5.10)0.8
PLT1-PLT2 (/microliter)190176 ± 176530 (11000–485000)−2826 ± 176163 (−377000 to 353000)0.001
PLT3-PLT2 (/microliter)217785 ± 194694 (−2000 to 75800)−90864 ± 164212 (−633000 to 140000)<0.001
ESR1-ESR2 (mm/h)28 ± 35 (−40 to 84)2.65 ± 35.53 (−70 to 74)0.03
ESR3-ESR2 (mm/h)3.5 ± 60 (−91 to 155)49.68 ± 40.11 (−42 to 115)0.002
CRP1-CRP2 (mg/L)97.11 ± 93.75 (20 to 303)27.61 ± 83.73 (−174 to 252)0.003
CRP3-CRP2 (mg/L)116.95 ± 115.22 (0 to 299)80.20 ± 64.38 (21.60 to 269)0.5
MAS: Macrophage Activation Syndrome, WBC: white blood cells, PMN: polymorphonuclear, Lymph: lymphocytes, Hgb: hemoglobin, PLT: platelet, ESR: erythrocyte sedimentation rate, and CRP: C-reactive protein. The previous laboratory records: WBC1, PMN1, and so forth. The laboratory data at the onset of MAS (MAS group) or active rheumatologic disease (control group): WBC2, PMN2, and so forth. The laboratory data 1 month after discharge from the hospital: WBC3, PMN3, and so forth.