Review Article

Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers

Figure 1

Sequence of lesions produced by Helicobacter pylori infection (cag-positive vacA s1m1 is the most aggressive strain). The precancerous cascade starts with atrophic gastritis, which progresses to intestinal metaplasia, dysplasia, and, finally, gastric cancer.