Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers

Figure 3

(a) RPRM methylation in tumor and nontumor adjacent mucosa (NTAM) tissues: higher methylation levels in tumor tissues are observed in comparison to NTAM in all six paired GC cases (taken from [63]). (b) Histogram representing the percentage of positive cases for Reprimo and other genes (APC, SHP1, CDH-1, ER, SEMA3B, and 3OST2) in 43 prospectively collected gastric cancer cases and 31 asymptomatic age- and gender-matched controls. Only Reprimo shows significant differences in plasma between gastric cancer and asymptomatic controls (taken with permission from [68]).

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