A Genetic Variant in miRNA-219-1 Is Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Kazakhs
Table 4
Stratification analyses between miR-219-1 rs107822G > A polymorphism and clinicopathological parameters of Kazakh ESCC patients.
Parameter
GG
GA
AA
GG
GA
AA
GA+AA
GG+GA
AA
Case/control
Adjusted OR (95% CI)
P
Adjusted OR (95% CI)
P
Adjusted OR (95% CI)
P
Adjusted OR (95% CI)
P value
Gender
Male
36/47
51/51
25/41
1.00
1.306 (0.729–2.337)
0.369
0.796 (0.411–1.540)
0.498
1.079 (0.635–1.832)
0.780
1.00
0.687 (0.386–1.221)
0.199
Female
19/30
37/53
30/50
1.00
1.102 (0.541–2.246)
0.789
0.947 (0.456–1.969)
0.885
1.027 (0.535–1.971)
0.936
1.00
0.889 (0.505–1.565)
0.684
Age
<57
27/45
33/54
28/48
1.00
0.968 (0.514–1.822)
0.920
0.715 (0.313–1.631)
0.424
0.893 (0.491–1.624)
0.711
1.00
0.737 (0.354–1.532)
0.413
≥57
38/32
45/50
27/43
1.00
0.758 (0.408–1.408)
0.380
0.529 (0.270–1.036)
0.062
0.652 (0.372–1.144)
0.135
1.00
0.620 (0.351–1.087)
0.099
Histologic grade
Well-differentiated
12
15
5
1.00
1.345 (0.569–3.184)
0.500
1.573 (0.49–5.051)
0.447
1.401 (0.619–3.170)
0.419
1.00
1.312 (0.460–3.742)
0.611
Moderately/poorly differentiated
53
83
30
Depth of invasion
T1+T2
16
33
13
1.00
0.603 (0.289–1.258)
0.178
0.461 (0.180–1.183)
0.107
0.564 (0.279–1.141)
0.111
1.00
0.641 (0.288–1.427)
0.276
T3+T4
44
59
19
Lymph node metastasis
No
34
47
23
1.00
1.261 (0.665–2.393)
0.477
0.620 (0.261–1.475)
0.280
1.058 (0.576–1.945)
0.856
1.00
0.537 (0.249–1.158)
0.113
Yes
31
51
12
TNM stage
I+II
38
58
19
1.00
1.075 (0.548–2.111)
0.833
1.234 (0.505–3.015)
0.644
1.113 (0.586–2.114)
0.744
1.00
1.180 (0.537–2.592)
0.681
III+IV
24
36
13
Stratification analysis to evaluate the effects of variant genotypes on the risk of ESCC by age and sex. Logistic regression analysis for the effects of miR-219-1 variants on risk of Kazakh ESCC with different histologic grade, depth of invasion, lymph node metastasis, and clinical stage.
