A Genetic Variant in miRNA-219-1 Is Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Kazakhs

Table 5

Distribution of miR-219-1 haplotypes and their association with Kazakh ESCC.

Haplotypes	Haplotype frequencies		OR (95% CI )
	Cases [(%)]	Controls [(%)]
	(n = 248)	(n = 300)
AC	70 (17.8)	90 (17.2)	1.049 (0.744–1.480)	0.075	0.78
AT	98 (24.8)	195 (37.4)	0.559 (0.419–0.747)	15.645	7.72 × 10^−5
GC	3 (0.7)	0 (0.00)	—	—	—
GT	223 (56.6)	237 (45.4)	1.597 (1.227–2.080)	12.139	4.97 × 10^−4

The combination order of SNP is as follows: rs107822G/A, rs213210 C/T.
Only haplotypes with frequencies of ≥0.03% are shown.
value for difference in haplotype frequencies between cases and control.
Haplotype frequencies were obtained using SHEsis Software (http://analysis.bio-x.cn/SHEsisMain.htm).