The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs

Table 2

Distribution levels for non-CYP450 variants on the DMET Plus platform.

Group	Type	All	MAF distribution
			Undetected	<0.01	>0.01
Transporters	ABC transporters	242	108 (0.44)	33 (0.14)	101 (0.42)
	Solute transporters	322	137 (0.42)	47 (0.15)	138 (0.43)
	ATPase, Cu^2+ transporters, alpha peptide	17	7 (0.41)	1 (0.06)	9 (0.53)
Transferases	Glucuronosyltransferases (UGTs)	116	58 (0.50)	11 (0.10)	47 (0.40)
	Sulfotransferases	138	45 (0.33)	18 (0.13)	75 (0.54)
	Glutathione S-transferase	88	42 (0.48)	4 (0.04)	42 (0.48)
	N-Acetyl glucosamine transferase	37	20 (0.54)	5 (0.13)	12 (0.32)
	Others (COMT, HNMT, MAT, NNMT, TPMT, QPRT, PNMT)	40	19 (0.48)	5 (0.12)	16 (0.40)
Dehydrogenases	ADHs; ALDHs, XDHs, G6PD	104	54 (0.52)	7 (0.07)	43 (0.41)
Monooxygenases	FMOs, MAOs, AOX	92	38 (0.41)	10 (0.11)	44 (0.48)
Reductases	VKORC1, HMGCRs, POR, CBR	43	16 (0.37)	7 (0.16)	20 (0.47)
Receptors	NR1, members 2 and 3	21	11 (0.52)	3 (0.14)	7 (0.33)
	PPAR, gamma, delta	53	13 (0.25)	2 (0.03)	38 (0.72)
	Nuclear receptor subfamily 3	12	5 (0.42)	5 (0.42)	2 (0.16)
	Others (RALBP1, SPN, APOA, RXRA, AHR, ARNT)	25	11 (0.44)	4 (0.16)	10 (0.40)
Miscellaneous	ALB, ARSA, CA5P AKAP, CDA, CES, PTGIS, CCDC, CROT, SPG, FAAH, EPHX, DCK, PON, TBXAS, TPSG, ORM, PGAP3, SERPINA, PPP1R9, PRSS53, RPL, TYMS	144	71 (0.49)	21 (0.15)	52 (0.36)

ABC, ATP-binding cassette transporters; ALDH, aldehyde dehydrogenase; ADH, alcohol dehydrogenase class 3; ALB, albumin; ARSA, arylsulfatase; AHR, aryl hydrocarbon receptor; AKAP, A-kinase anchor proteins; APOA, apolipoprotein receptor, subtype A; AOX, alternative oxidase; CA5P, carbonic anhydrase; CBR, carbonyl reductase; CCDC, coiled-coil domain-containing protein; CDA, cytidine deaminase; CES, carboxylesterase; COMT, catechol-O-methyl transferase; CROT, peroxisomal carnitine O-octanoyltransferase; DCK, deoxycytidine kinase; EPHX, microsomal epoxide hydrolase; FAAH, fatty acid amide hydrolase; FMO, flavin-containing monooxygenase; G6PD, glucose 6-phosphate dehydrogenase; HNMT, histamine N-methyltransferase; MAO, monoamine oxidase; MAT, methionine adenosyl transferases; NNMT, nicotinamide N-methyltransferase; NR1, nucleic acid receptor, group 1; ORM, orosomucoid; PGAP3, post-GPI attachment to proteins 3; PON, serum paraoxonase/arylesterase; POR, cytochrome P450 reductase; PPAR, peroxisome proliferator-activated receptors; PNMT, phenylethanolamine N-methyltransferase; PTGIS, prostaglandin-I synthase; QPRT, quinolinate phosphoribosyltransferase; PPP1R9, protein phosphatase 1, regulatory subunit 9B; PRSS53; serine protease, 53; RALBP1, ralA binding protein 1; RPL, ribosomal protein-binding receptor; RXRA, retinoic acid receptor; SERPINA, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin); SPG, spastic paraplegia; SPN, sialophorin receptor; TBXAS, thromboxane A synthase 1 (platelet); TYMS, thymidylate synthetase; TPMT, thiopurine S-methyltransferase; TPSG, tryptase; XDH, xanthine dehydrogenases.