High Serum Level of β2-Microglobulin in Late Posttransplant Period Predicts Subsequent Decline in Kidney Allograft Function: A Preliminary Study
Table 2
Significant predictors of eGFR at different time points of late posttransplant period.
Predictive variables
Univariate linear regression
Multivariate linear regression
Beta
SE
value
Beta
SE
value
eGFR at baseline (mL/min/1.73 m2),
Log proteinuria/creatinine†
−0.488
0.104
<0.001
−0.406
0.153
0.012
Impaired initial function‡
−0.235
0.112
0.040
Log mean arterial pressure†
−0.502
0.099
<0.001
−0.332
0.153
0.037
Previous acute rejection‡
−0.241
0.112
0.035
eGFR after 1 year of follow-up (mL/min/1.73 m2),
eGFR at baseline
0.870
0.057
<0.001
0.721
0.091
<0.001
Log proteinuria/creatinine†
−0.476
0.105
<0.001
Serum β2MG
−0.538
0.137
<0.001
−0.291
0.091
0.003
Impaired initial function‡
−0.233
0.113
0.042
Log mean arterial pressure†
−0.436
0.103
<0.001
Time after transplantation
−0.262
0.111
0.021
eGFR after 2 years of follow-up (mL/min/1.73 m2),
eGFR at baseline
0.838
0.063
<0.001
0.649
0.101
<0.001
Log proteinuria/creatinine†
−0.473
0.105
<0.001
Serum β2MG
−0.527
0.138
<0.001
−0.302
0.098
0.004
Impaired initial function‡
−0.230
0.113
0.030
Log mean arterial pressure†
−0.447
0.103
<0.001
Time after transplantation
−0.332
0.108
0.003
−0.148
0.097
0.135
Previous acute rejection‡
−0.261
0.112
0.023
β2MG: β2-microglobulin; eGFR: estimated glomerular filtration rate; beta: standardized regression coefficient; SE: standard error of beta; : number of patients investigated; only variables that significantly influenced the eGFR in univariate analysis are included; †natural log-transformed variables; ‡impaired initial function and acute rejection scored in points.
