The Prognostic Value of Pyrosequencing-Detected MGMT Promoter Hypermethylation in Newly Diagnosed Patients with Glioblastoma

Table 2

Receiver Operating Characteristic (ROC) analyses showing the best cut-off values of MGMT predicting overall survival (left) and progression-free survival (right) in the study sample ().

	Progression-free survival	Overall survival
AUC (95% CIs)	0.71 (0.57–0.83)	0.65 (0.50–0.78)
Criterion (cut-off)	≥19%	≥13%
Sensitivity	73%	58%
Specificity	77%	70%
value	0.0054	0.057

AUC: area under the curve; MGMT: O6-methylguanine-DNA-methyltransferase.