The Prognostic Value of Pyrosequencing-Detected MGMT Promoter Hypermethylation in Newly Diagnosed Patients with Glioblastoma

Table 4

Cox proportional hazard models predicting overall survival (dependent variable).

	Univariate analysis			Multivariable analysis
	HR	95% CIs	value	HR	95% CIs	value
Gender; (men versus women)	0.79	0.84–1.83	0.59
Age; (each year)	1.08	1.03–1.12	0.0008
Surgery; (done versus not done)	0.31	0.11–0.96	0.0439
Radiotherapy; (done versus not done)	0.08	0.02–0.24	<0.0001	0.10	0.02–0.42	0.0021
Chemotherapy; (done versus not done)	0.26	0.07–1.01	0.052	0.15	0.03–0.86	0.033
MGMT methylation; (each unit increase)	0.99	0.97–1.03	0.96
MGMT methylation; (>13% versus ≤13%)	0.57	0.24–1.31	0.19	0.33	0.12–0.92	0.035

95% CIs: 95% confidence intervals; HR: hazard ratio.