Copeptin Testing in Acute Myocardial Infarction: Ready for Routine Use?

Table 1

Overview of clinical conditions other than AMI associated with increased copeptin concentrations.

Condition	Potential implications of elevated copeptin concentrations	References
Stable coronary artery disease	Predictor for major adverse cardiovascular events	[51]
Heart failure	Associated with mortality risk, risk of hospitalization, and disease severity	[52–56]
Type 2 diabetes	Potential marker for peripheral arterial disease and diabetic chronic kidney disease. Potential marker for cardiovascular and all-cause mortality	[57–59]
Pneumonia	Marker for adverse outcome	[60, 61]
Acute exacerbation of chronic obstructive pulmonary disease	Potential prognostic marker for short-term and long-term outcome	[62]
Sepsis/shock	Promising independent prognostic markers for mortality	[33, 35, 63]
Survivors of cardiac arrest	Potentially useful for risk stratification at the time of hospital admission	[64]
Pulmonary arterial hypertension	Potentially useful in the prediction of poor outcome	[65]
Stroke/transient ischaemic attack	Risk stratification for patients with transient ischaemic attack and stroke	[66–68]
Traumatic brain injury	Probable marker of progressive haemorrhagic injury, acute traumatic coagulopathy, and mortality	[69–71]
Intracerebral haemorrhage	Useful to predict adverse clinical outcomes	[72, 73]
Carotid endarterectomy	Probable predictor of perioperative stroke	[74]
CABG surgery	Postoperative copeptin concentrations might predict delirium and cognitive dysfunction	[75]
Chronic kidney disease	Potential marker for the development/progression of atherosclerosis	[76]
Autosomal dominant polycystic kidney disease	Potential role in disease progression	[77, 78]
Carbon monoxide poisoning	Associated with intoxication severity and potentially useful to predict delayed neurological sequelae	[79]
Polycystic ovary syndrome	Relationship with cardiometabolic parameters (e.g., carotid intima media thickness)	[80]
Endometriosis	Direct association with disease severity	[81]
Preeclampsia	Associated with increased risk for preeclampsia already before clinical diagnosis	[82, 83]
Acute pancreatitis	Marker for disease severity and local complications	[37, 84]
Liver cirrhosis	Associated with the severity of disease and with the risk of death or liver transplantation	[85]
Sickle cell anaemia	Differentiation between mild or severe sickle cell anaemia	[86]

Aortocoronary bypass grafting (CABG).