Table 1: Overview of clinical conditions other than AMI associated with increased copeptin concentrations.

ConditionPotential implications of elevated copeptin concentrationsReferences

Stable coronary artery diseasePredictor for major adverse cardiovascular events[51]
Heart failureAssociated with mortality risk, risk of hospitalization, and disease severity[5256]
Type 2 diabetes Potential marker for peripheral arterial disease and diabetic chronic kidney disease. Potential marker for cardiovascular and all-cause mortality[5759]
PneumoniaMarker for adverse outcome[60, 61]
Acute exacerbation of chronic obstructive pulmonary diseasePotential prognostic marker for short-term and long-term outcome[62]
Sepsis/shockPromising independent prognostic markers for mortality [33, 35, 63]
Survivors of cardiac arrestPotentially useful for risk stratification at the time of hospital admission[64]
Pulmonary arterial hypertensionPotentially useful in the prediction of poor outcome[65]
Stroke/transient ischaemic attackRisk stratification for patients with transient ischaemic attack and stroke[6668]
Traumatic brain injuryProbable marker of progressive haemorrhagic injury, acute traumatic coagulopathy, and mortality[6971]
Intracerebral haemorrhageUseful to predict adverse clinical outcomes [72, 73]
Carotid endarterectomyProbable predictor of perioperative stroke [74]
CABG surgeryPostoperative copeptin concentrations might predict delirium and cognitive dysfunction [75]
Chronic kidney diseasePotential marker for the development/progression of atherosclerosis[76]
Autosomal dominant polycystic kidney diseasePotential role in disease progression[77, 78]
Carbon monoxide poisoningAssociated with intoxication severity and potentially useful to predict delayed neurological sequelae [79]
Polycystic ovary syndromeRelationship with cardiometabolic parameters (e.g., carotid intima media thickness)[80]
EndometriosisDirect association with disease severity[81]
PreeclampsiaAssociated with increased risk for preeclampsia already before clinical diagnosis[82, 83]
Acute pancreatitisMarker for disease severity and local complications[37, 84]
Liver cirrhosisAssociated with the severity of disease and with the risk of death or liver transplantation[85]
Sickle cell anaemiaDifferentiation between mild or severe sickle cell anaemia[86]

Aortocoronary bypass grafting (CABG).