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Disease Markers
Volume 2015, Article ID 640263, 8 pages
http://dx.doi.org/10.1155/2015/640263
Research Article

Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma

1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
2Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
3Clinical Trial Center, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
4Department of Neurology, Peking University First Hospital, Beijing 100034, China
5Department of Medical Oncology, Guangxi Traditional Chinese Medical University, Ruikang Hospital, Nanning 530011, China
6Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
7Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
8Department of Oncology, Huizhou Municipal Central Hospital, Huizhou 516001, China
9Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China

Received 11 February 2015; Accepted 15 April 2015

Academic Editor: Silvia Persichilli

Copyright © 2015 Hang Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods. Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected. The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results. The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, ). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all ). Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (, hazard ratio = 1.635, 95% CI 1.073–2.493) in HNSCC patients. Conclusion. ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.