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Disease Markers
Volume 2015, Article ID 684794, 7 pages
Research Article

Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

Department of Orthopedics, The General Hospital of Chinese Army, Beijing 100853, China

Received 25 December 2014; Revised 8 February 2015; Accepted 12 February 2015

Academic Editor: Markus Herrmann

Copyright © 2015 Qingmeng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.