OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data

Table 2

Mutations and their allele frequencies observed in the OGG1 gene in breast cancer patients.

Mutation/exon; Chr3 (GRCh37)	Patients		Controls		^aOdds ratio (95% CI)	^b value
	Number	Allele frequency; Minor/major	Number	Allele frequency; Minor/major
g.9792260 insert_T Intron 1	34	T 0.09/0.91	07	T 0.35/0.65	3.80 (1.67 to 8.66)	0.001
g.9793680G>A Intron 3 (rs55846930)	19	A 0.05/G 0.95	00	A 00/G 1.0	14.65 (1.95 to 109.90)	0.009
g.9793748G>A Intron 3	14	A 0.04/G 0.96	00	A 00/G 1.0	10.70 (1.40 to 81.64)	0.02
g.9798336T>G Intron 5	10	G 0.03/T 0.97	06	G 0.40/T 0.60	1.25 (0.45 to 3.46)	0.67
g.9798349T>A Intron 5	34	A 0.09/T 0.91	02	A 0.10/T0.90	13.30 (3.18 to 55.70)	0.0004
g.9792109delT splice site Intron 1	26	0.07/T 0.93	00	00/T 1.0	20.07 (2.71 to 148.53)	0.003
g.9798307T>G splice site Intron 5	16	G 0.04/T 0.96	00	G 00/T 1.0	12.11 (1.60 to 91.70)	0.01
g.9798502T>G splice site Intron 6	18	G 0.05/T 0.95	00	G 00/T 1.0	13.68 (1.82 to 102.90)	0.01
g.9800972T>G splice site intron 7a	36	G 0.10/T 0.90	00	G 00/T 1.0	28.85 (3.87 to 207.70)	0.001
g.9798848G>A 3′UTR	37	A 0.10/G 0.90	00	A 00/G 1.0	29.20 (3.98 to 213.74)	0.001
g.9798896T>C 3′UTR	48	C 0.13/T 0.87	03	C 0.15/T 0.85	12.85 (3.97 to 41.56)	<0.0001
g.9793544T>G Exon 3, Val159Gly	18	G 0.05/T 0.95	00	G 00/T 1.0	13.68 (1.82 to 102.90)	0.01
g.9796483G>A Exon 4, Gly221Arg (TMP_ESP_3_9796483)	22	A 0.06/G 0.94	00	A 00/G 1.0	16.85 (2.26 to 125.53)	0.005
g.9798773C>G Exon 6d Ser326Cys (rs1052133) (CM993185)	24	G 0.06/C 0.94	00	G 00/C 1.0	18.45 (2.49 to 136.99)	0.004
g.9807669G>A Exon 8, Trp375STOP	17	A 0.05/G 0.95	00	A 00/G 1.0	12.90 (1.71 to 97.28)	0.01

OR: odds ratio; CI: confidence interval. ^aORs for logistic regression analysis. ^b, by -test for trend.