OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data

Table 5

Association of OGG1 mutations with family history and menopausal age in breast cancer patients in present study.

Mutation/exon; Chr3 (GRCh37)	Family history of cancer			Menopause at ≤50 years			Menopause at >50 years
	Patients (%)	Control (%)	OR (95% CI), value	Patients (%)	Control (%)	OR (95% CI), value	Patients (%)	Control (%)	OR (95% CI), value
g.9792260 ins_T Intron 1	8 (8.2)	02 (40)	3.0 (0.6 to 14.3), 0.1	17 (11.0)	4 (36.4)	3.2 (1.1 to 9.6), 0.04	5 (11.1)	2 (25)	1.8 (0.3 to 9.4), 0.4
g.9793680G>A Intron 3 (rs55846930)	12 (12.2)	0	9.1 (1.2 to 70.5), 0.03	11 (7.1)	0	8.2 (1.0 to 64.0), 0.05	4 (8.8)	0	2.9 (0.3 to 26.1), 0.3
g.9793748G>A Intron 3	5 (5.1)	0	3.7 (0.4 to 32.2), 0.2	10 (6.5)	0	7.4 (0.9 to 58.5), 0.06	4 (8.8)	0	2.9 (0.3 to 26.1), 0.3
g.9798336T>G Intron 5	6 (6.1)	01 (20)	4.5 (0.5 to 37.6), 0.1	08 (5.2)	2 (18.2)	2.9 (0.6 to 13.9), 0.2	2 (4.4)	2 (25)	0.7 (0.1 to 5.1), 0.7
g.9798349T>A Intron 5	6 (6.1)	01 (20)	4.5 (0.5 to 37.6), 0.1	19 (12.3)	01 (9.9)	14.6 (1.9 to 110.5), 0.009	4 (8.8)	1 (12.5)	2.9 (0.3 to 26.1), 0.3
g.9792109delT splice site Intron 1	4 (4.1)	0	3.0 (0.3 to 26.9), 0.3	13 (8.4)	0	9.8 (1.3 to 75.3), 0.03	1 (2.2)	0	0.7 (0.04 to 11.5), 0.8
g.9798307T>G splice site Intron 5	2 (2.0)	0	1.5 (0.1 to 16.5), 0.7	06 (5.2)	0	4.4 (0.5 to 36.6), 0.2	4 (8.8)	0	2.9 (0.3 to 26.1), 0.3
g.9798502T>G splice site Intron 6	12 (12.2)	0	9.1 (1.2 to 70.5), 0.03	06 (5.2)	0	4.4 (0.5 to 36.6), 0.2	3 (6.6)	0	2.2 (0.2 to 20.9), 0.5
g.9800972T>G splice site Intron 7a	0	0	00	16 (10.3)	0	12.2 (1.6 to 92.7), 0.02	6 (13.2)	0	4.4 (0.5 to 36.6), 0.2
g.9798848G>A 3′UTR	5 (5.1)	0	3.7 (0.4 to 32.2), 0.2	14 (9.0)	0	10.6 (1.4 to 81.1), 0.02	3 (6.6)	0	2.2 (0.2 to 20.9), 0.5
g.9798896T>C 3′UTR	9 (9.2)	01 (20)	6.8 (0.8 to 54.0), 0.07	16 (10.3)	01 (9.9)	12.2 (1.6 to 92.7), 0.02	3 (6.6)	1 (12.5)	2.2 (0.2 to 20.9), 0.5
g.9793544T>G Exon 3, Val159Gly	4 (4.1)	0	3.0 (0.3 to 26.9), 0.3	02 (1.3)	0	1.4 (0.1 to 15.9), 0.8	1 (2.2)	0	0.7 (0.04 to 11.5), 0.8
g.9796483G>A Exon 4, Gly221Arg (TMP_ESP_3_9796483)	2 (2.0)	0	1.5 (0.1 to 16.5), 0.7	04 (2.6)	0	2.9 (0.3 to 26.1), 0.3	2 (4.4)	0	1.4 (0.1 to 15.9), 0.8
g.9798773C>G Exon 6d, Ser326Cys; (rs1052133) (CM993185)	19 (19.4)	0	14.6 (2.0 to 109.9), 0.009	13 (8.4)	0	9.8 (1.3 to 75.3), 0.03	3 (6.6)	0	2.2 (0.2 to 20.9), 0.5
g.9807669G>A Exon 8 Trp375STOP	4 (4.1)	0	3.0 (0.3 to 26.9), 0.3	08 (5.2)	0	5.9 (0.7 to 47.5), 0.1	1 (2.2)	0	0.7 (0.04 to 11.5), 0.8

OR: odds ratio; CI: confidence interval. ORs for logistic regression analysis. , by -test for trend.