3-Nitrotyrosine Modified Proteins in Atherosclerosis

Table 2

Nitration sites in plasma proteins identified by mass spectrometry.

Protein	Nitrated Tyr	Effect	References
ApoA-1^1	Y166 and Y192	Decreased activation of LCAT and ABCA1	[59, 77–79]
ApoB-100^2	Y276, Y583, Y666, Y720, Y2524, Y3139, Y3295, Y3489, Y4141	Increased affinity for LOX-1, CD36, SR-A	[69]
Fibrinogen chain^1	Y292, Y422	Accelerated clot formation	[55]
Ig gamma-1 chain C region^1	Y161, Y290	Unknown	[18]
Ig kappa chain C region^1	Y32, Y84	Unknown	[18]
Ig lambda chain C region^1	Y84	Unknown	[18]
Ig mu chain C region^1	Y276	Unknown	[18]
Ig heavy chain V-III^1	Y33, Y80, Y95	Unknown	[18]
Zinc finger and BTB domain-containing protein 1^1	Y83	Unknown	[18]
Protein EFR3 homolog B^1	Y669	Unknown	[18]

 ¹Data from proteins immunocaptured from individuals diagnosed with CVD.
²Data from an electronegative LDL fraction isolated from plasma from healthy humans.