Research Article
Radiosynthesis, In Vivo Biological Evaluation, and Imaging of Brain Lesions with [123I]-CLINME, a New SPECT Tracer for the Translocator Protein
Table 1
Biodistribution of [123I]-CLINME in SD male rats.
| %ID/g | 5 min | 15 min | 30 min | 1 hour | 3 hours | 6 hours |
| Liver | 0.70 ± 0.10 | 0.68 ± 0.07 | 0.51 ± 0.07 | 0.42 ± 0.07 | 0.23 ± 0.01 | 0.21 ± 0.05 | Spleen | 2.00 ± 0.55 | 2.65 ± 0.40 | 2.21 ± 0.15 | 1.76 ± 0.12 | 1.02 ± 0.14 | 0.67 ± 0.09 | Kidney | 1.82 ± 0.20 | 1.75 ± 0.07 | 1.78 ± 0.18 | 1.16 ± 0.18 | 0.70 ± 0.05 | 0.51 ± 0.09 | Lungs | 7.88 ± 0.62 | 3.53 ± 0.44 | 2.45 ± 0.30 | 1.68 ± 0.10 | 0.95 ± 0.12 | 0.68 ± 0.08 | Heart | 3.28 ± 0.30 | 3.53 ± 0.23 | 3.32 ± 0.31 | 2.601 ± 0.13 | 1.28 ± 0.13 | 0.72 ± 0.14 | Blood | 0.18 ± 0.02 | 0.09 ± 0.01 | 0.08 ± 0.01 | 0.06 ± 0.00 | 0.04 ± 0.00 | 0.03 ± 0.00 | Brain | 0.20 ± 0.02 | 0.10 ± 0.01 | 0.08 ± 0.00 | 0.06 ± 0.01 | 0.03 ± 0.00 | 0.02 ± 0.00 | Olfactory bulbs | 0.38 ± 0.03 | 0.28 ± 0.04 | 0.34 ± 0.01 | 0.26 ± 0.05 | 0.25 ± 0.01 | 0.17 ± 0.05 | Thyroid | 4.62 ± 2.17 | 5.62 ± 1.24 | 7.37 ± 2.14 | 6.46 ± 2.26 | 3.41 ± 1.10 | 4.11 ± 1.15 | Adrenals | 2.89 ± 0.48 | 4.71 ± 0.26 | 7.55 ± 1.38 | 6.77 ± 0.54 | 6.65 ± 0.56 | 8.34 ± 0.71 |
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Results are mean ± SD percent of injected dose per gram (%ID/g), = 3-4 rats.
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