Radiosynthesis, In Vivo Biological Evaluation, and Imaging of Brain Lesions with [¹²³I]-CLINME, a New SPECT Tracer for the Translocator Protein

Table 1

Biodistribution of [¹²³I]-CLINME in SD male rats.

%ID/g	5 min	15 min	30 min	1 hour	3 hours	6 hours
Liver	0.70 ± 0.10	0.68 ± 0.07	0.51 ± 0.07	0.42 ± 0.07	0.23 ± 0.01	0.21 ± 0.05
Spleen	2.00 ± 0.55	2.65 ± 0.40	2.21 ± 0.15	1.76 ± 0.12	1.02 ± 0.14	0.67 ± 0.09
Kidney	1.82 ± 0.20	1.75 ± 0.07	1.78 ± 0.18	1.16 ± 0.18	0.70 ± 0.05	0.51 ± 0.09
Lungs	7.88 ± 0.62	3.53 ± 0.44	2.45 ± 0.30	1.68 ± 0.10	0.95 ± 0.12	0.68 ± 0.08
Heart	3.28 ± 0.30	3.53 ± 0.23	3.32 ± 0.31	2.601 ± 0.13	1.28 ± 0.13	0.72 ± 0.14
Blood	0.18 ± 0.02	0.09 ± 0.01	0.08 ± 0.01	0.06 ± 0.00	0.04 ± 0.00	0.03 ± 0.00
Brain	0.20 ± 0.02	0.10 ± 0.01	0.08 ± 0.00	0.06 ± 0.01	0.03 ± 0.00	0.02 ± 0.00
Olfactory bulbs	0.38 ± 0.03	0.28 ± 0.04	0.34 ± 0.01	0.26 ± 0.05	0.25 ± 0.01	0.17 ± 0.05
Thyroid	4.62 ± 2.17	5.62 ± 1.24	7.37 ± 2.14	6.46 ± 2.26	3.41 ± 1.10	4.11 ± 1.15
Adrenals	2.89 ± 0.48	4.71 ± 0.26	7.55 ± 1.38	6.77 ± 0.54	6.65 ± 0.56	8.34 ± 0.71

Results are mean ± SD percent of injected dose per gram (%ID/g), = 3-4 rats.