Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease in Carriers of the APOEε4 Allele

Table 3

Multinomial logistic regression models of rs4880-T (SOD2) and APOEε4 allele in aMCI and AD patients.

Gene		Model	aMCI		AD
			OR CI 95%		OR CI 95%
APOE		ε4 (+)	2.54 (1.68–3.83)	<0.001	4.15 (2.85–6.05)	<0.001
SOD2	Additive	TT	1.03 (0.59–1.80)	0.914	0.91 (0.57–1.46)	0.708
	Additive	TC	1.34 (0.85–2.11)	0.206	0.85 (0.57–1.25)	0.415
	Dominant	TC/TT	1.25 (0.81–1.93)	0.318	0.87 (0.60–1.26)	0.455
	Recessive	TT	0.84 (0.53–1.33)	0.455	1.01 (0.68–1.50)	0.943
	Additive	ε4 (+) TC	3.54 (1.82–6.86)	<0.001	3.48 (1.94–6.27)	<0.001
	Additive	ε4 (+) TT	2.39 (1.00–5.74)	0.051	3.28 (1.54–6.99)	0.002
	Dominant	ε4 (+) TC/TT	3.17 (1.80–5.84)	<0.001	3.41 (2.01–5.80)	<0.001
	Recessive	ε4 (+) TT	1.95 (0.89–4.27)	0.095	4.00 (2.00–7.99)	0.002

Control subjects were the reference category in all models. OR, odds ratio. CI, confidence interval.