Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome

Table 4

Relationship between mediators and the outcomes (Mann-Whitney test).

		Yes; Med. (P25–P75)	No; Med. (P25–P75)	P
ICU admission
IL-6; pg/mL	24 h	569 (177–1440)	190 (131–439)	0.006
	48 h	315 (140–567)	117 (60–204)	0.001
	72 h	295 (129–585)	53.7 (29.1–171)	0.001
IL-10; pg/mL	72 h	3.35 (0.1–15.2)	0.1 (0.1–4.0)	0.0019
ICAM-1; ng/mL	72 h	272 (206–445)	222 (191–316)	0.048
ARDS
IL-6; pg/mL	72 h	419 (135–622)	145 (36.4–429)	0.036
IL-10; pg/mL	Admission	128 (102–187)	51.1 (16.4–146)	0.007
	24 h	13.1 (8.3–46.8)	3.6 (0.1–14.3)	0.003
	48 h	6.7 (0.1–23.3)	0.1 (0.1–4.3)	0.035
	72 h	10.8 (1.2–16.3)	0.1 (0.1–5.4)	0.015
ICAM-1; ng/mL	48 h	342 (234–457)	225 (196–311)	0.031
MODS
IL-6; pg/mL	48 h	319 (242–711)	169 (86–344)	0.034
	72 h	405 (129–1184)	112 (36–271)	0.002
IL-10; pg/mL	24 h	10.2 (3.6–25.6)	1.2 (0.1–14.3)	0.008
	72 h	10.8 (1.2–17.7)	0.1 (0.1–3.6)	<0.001
ICAM-1; ng/mL	24 h	306 (220–370)	202 (178–287)	0.018
	48 h	296 (230–486)	220 (194–300)	0.034
	72 h	307 (200–614)	240 (202–322)	0.002
TNFα; pg/mL	48 h	17.8 (10.4–24)	10.3 (6.4–16.4)	0.016
Death
IL-6; pg/mL	72 h	441 (197–1527)	144 (47–445)	0.024
IL-10; pg/mL	48 h	10.9 (0.1–16.8)	0.1 (0.1–4)	0.025
	72 h	19.1 (11.6–40.6)	0.1 (0.1–5.0)	0.001