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Disease Markers
Volume 2015 (2015), Article ID 761939, 5 pages
http://dx.doi.org/10.1155/2015/761939
Research Article

Association of Plasma Myeloperoxidase Level with Risk of Coronary Artery Disease in Patients with Type 2 Diabetes

1Department of Endocrinology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China
2Shandong Clinical Medical Center of Endocrinology and Metabolism, No. 324, Jing 5 Road, Jinan, Shandong 250021, China
3Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, No. 324, Jing 5 Road, Jinan, Shandong 250021, China
4Department of Cardiology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China

Received 16 February 2015; Revised 9 June 2015; Accepted 11 June 2015

Academic Editor: Irene Rebelo

Copyright © 2015 Ping Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients. Methods. 339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group. Results. Compared to non-CAD group, CAD group had higher level of plasma MPO (). Multiple linear regression analysis showed that plasma MPO level was correlated with Gensini score. Multiple logistic analysis showed that the odds ratios for CAD across increasing tertiles of MPO level were 1.191 (0.971–1.547) and 1.488 (1.115–2.228) (, versus 1st tertile of MPO level, resp.) by adjusting for age, sex, and other conventional risk factors for CAD. The subjects were stratified into nine groups according to tertiles of MPO and HbA1c. The odds ratio for CAD was significantly higher in group with highest levels of MPO and HbA1c (OR = 4.08, ). Conclusion. Plasma MPO level was positively correlated with the degree of coronary artery stenosis in type 2 diabetic patients, and increasing blood glucose might amplify the association between MPO and CAD.