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Disease Markers
Volume 2015, Article ID 785461, 8 pages
http://dx.doi.org/10.1155/2015/785461
Research Article

CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer

1Department of Urology, University Hospital, University of Zurich, 8091 Zurich, Switzerland
2Institute of Surgical Pathology, University Hospital, University of Zurich, 8091 Zurich, Switzerland
3Institute of Pharmaceutical Sciences, ETH Zurich, 8093 Zurich, Switzerland

Received 1 August 2015; Accepted 27 September 2015

Academic Editor: Felix Chun

Copyright © 2015 Marian S. Wettstein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, H.-R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. I. Epstein, M. B. Amin, V. R. Reuter, and F. K. Mostofi, “The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder,” The American Journal of Surgical Pathology, vol. 22, no. 12, pp. 1435–1448, 1998. View at Google Scholar
  3. M. Sanchez-Carbayo, N. D. Socci, J. Lozano, F. Saint, and C. Cordon-Cardo, “Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays,” Journal of Clinical Oncology, vol. 24, no. 5, pp. 778–789, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. R. L. Lapham, J. Y. Ro, G. A. Staerkel, and A. G. Ayala, “Pathology of transitional cell carcinoma of the bladder and its clinical implications,” Seminars in Surgical Oncology, vol. 13, no. 5, pp. 307–318, 1997. View at Google Scholar · View at Scopus
  5. R. S. Svatek, B. K. Hollenbeck, S. Holmäng et al., “The economics of bladder cancer: costs and considerations of caring for this disease,” European Urology, vol. 66, no. 2, pp. 253–262, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. R. J. Sylvester, A. P. M. van der Meijden, W. Oosterlinck et al., “Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials,” European Urology, vol. 49, no. 3, pp. 466–477, 2006. View at Google Scholar
  7. H. G. Juffs, M. J. Moore, and I. F. Tannock, “The role of systemic chemotherapy in the management of muscle-invasive bladder cancer,” The Lancet Oncology, vol. 3, no. 12, pp. 738–747, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Fradet and L. Lacombe, “Can biological markers predict recurrence and progression of superficial bladder cancer?” Current Opinion in Urology, vol. 10, no. 5, pp. 441–445, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Lee and M. J. Droller, “The natural history of bladder cancer: implications for therapy,” Urologic Clinics of North America, vol. 27, no. 1, pp. 1–13, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. P. J. Wild, A. Herr, C. Wissmann et al., “Gene expression profiling of progressive papillary noninvasive carcinomas of the urinary bladder,” Clinical Cancer Research, vol. 11, no. 12, pp. 4415–4429, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Fristrup, B. P. Ulhøi, K. Birkenkamp-Demtrder et al., “Cathepsin E, Maspin, Plk1, and survivin are promising prognostic protein markers for progression in non-muscle invasive bladder cancer,” American Journal of Pathology, vol. 180, no. 5, pp. 1824–1834, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. A. S. Sarkis, G. Dalbagni, C. Cordon-Cardo et al., “Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression,” Journal of the National Cancer Institute, vol. 85, no. 1, pp. 53–59, 1993. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Cordes, M. Kluth, D. Zygis et al., “PTEN deletions are related to disease progression and unfavourable prognosis in early bladder cancer,” Histopathology, vol. 63, no. 5, pp. 670–677, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-C. Pan, Y.-H. Chang, K.-K. Chen, H.-J. Yu, C.-H. Sun, and D. M. T. Ho, “Prognostic significance of the 2004 WHO/ISUP classification for prediction of recurrence, progression, and cancer-specific mortality of non-muscle-invasive urothelial tumors of the urinary bladder: a clinicopathologic study of 1,515 cases,” American Journal of Clinical Pathology, vol. 133, no. 5, pp. 788–795, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. B. W. G. Van Rhijn, L. Liu, A. N. Vis et al., “Prognostic value of molecular markers, sub-stage and European Organisation for the Research and Treatment of Cancer risk scores in primary T1 bladder cancer,” BJU International, vol. 110, no. 8, pp. 1169–1176, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Palou, F. Algaba, I. Vera, O. Rodriguez, H. Villavicencio, and M. Sanchez-Carbayo, “Protein expression patterns of ezrin are predictors of progression in T1G3 bladder tumours treated with nonmaintenance bacillus Calmette-Guérin,” European Urology, vol. 56, no. 5, pp. 829–836, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. B. W. G. van Rhijn, T. H. van Der Kwast, L. Liu et al., “The FGFR3 mutation is related to favorable pT1 bladder cancer,” Journal of Urology, vol. 187, no. 1, pp. 310–314, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. B. W. G. Van Rhijn, T. C. M. Zuiverloon, A. N. Vis et al., “Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer,” European Urology, vol. 58, no. 3, pp. 433–441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. S. S. Alkhateeb, M. Neill, S. Bar-Moshe et al., “Long-term prognostic value of the combination of EORTC risk group calculator and molecular markers in non-muscle-invasive bladder cancer patients treated with intravesical Bacille Calmette-Gurin,” Urology Annals, vol. 3, no. 3, pp. 119–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Gao, K. Dong, and H. Zhang, “The roles of CD73 in cancer,” BioMed Research International, vol. 2014, Article ID 460654, 9 pages, 2014. View at Publisher · View at Google Scholar
  21. G. G. Yegutkin, “Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade,” Biochimica et Biophysica Acta: Molecular Cell Research, vol. 1783, no. 5, pp. 673–694, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Ghiringhelli, M. Bruchard, F. Chalmin, and C. Rébé, “Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 473712, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Zhi, S. Chen, P. Zhou et al., “RNA interference of ecto-5′-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion,” Clinical and Experimental Metastasis, vol. 24, no. 6, pp. 439–448, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Sadej and A. C. Skladanowski, “Dual, enzymatic and non-enzymatic, function of ecto-5′-nucleotidase (en, CD73) in migration and invasion of A375 melanoma cells,” Acta Biochimica Polonica, vol. 59, no. 4, pp. 647–652, 2012. View at Google Scholar · View at Scopus
  25. B. Zhang, “CD73 promotes tumor growth and metastasis,” OncoImmunology, vol. 1, no. 1, pp. 67–70, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Burnstock and F. Di Virgilio, “Purinergic signalling and cancer,” Purinergic Signalling, vol. 9, no. 4, pp. 491–540, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Stella, L. Bavaresco, E. Braganhol et al., “Differential ectonucleotidase expression in human bladder cancer cell lines,” Urologic Oncology: Seminars and Original Investigations, vol. 28, no. 3, pp. 260–267, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Durak, H. Perk, M. Kavutçu, O. Canbolat, Ö. Akyol, and Y. Bedük, “Adenosine deaminase, 5′nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human bladder tissues,” Free Radical Biology and Medicine, vol. 16, no. 6, pp. 825–831, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. P. D. Wilson, I. C. Summerhayes, G. M. Hodges, L. K. Trejdosiewicz, and W. J. Nathrath, “Cytochemical markers of bladder carcinogenesis,” The Histochemical Journal, vol. 13, no. 6, pp. 989–1007, 1981. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Rockenbach, E. Braganhol, F. Dietrich et al., “NTPDase3 and ecto-5′-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression,” Purinergic Signalling, vol. 10, pp. 421–430, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Kononen, L. Bubendorf, A. Kallioniemi et al., “Tissue microarrays for high-throughput molecular profiling of tumor specimens,” Nature Medicine, vol. 4, no. 7, pp. 844–847, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Poyet, B. Jentsch, T. Hermanns et al., “Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer,” BMC Clinical Pathology, vol. 14, no. 1, article 10, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. F. R. Fritzsche, W. Weichert, A. Röske et al., “Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer,” BMC Cancer, vol. 8, article 381, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Nocito, L. Bubendorf, E. M. Tinner et al., “Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade,” The Journal of Pathology, vol. 194, no. 3, pp. 349–357, 2001. View at Publisher · View at Google Scholar
  35. B. W. G. Van Rhijn, A. N. Vis, T. H. Van Der Kwast et al., “Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome,” Journal of Clinical Oncology, vol. 21, no. 10, pp. 1912–1921, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. H. K. Oh, J.-I. Sin, J. Choi, S. H. Park, T. S. Lee, and Y. S. Choi, “Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration,” Journal of Gynecologic Oncology, vol. 23, no. 4, pp. 274–281, 2012. View at Google Scholar · View at Scopus
  37. A. Supernat, A. Markiewicz, M. Welnicka-Jaskiewicz et al., “CD73 expression as a potential marker of good prognosis in breast carcinoma,” Applied Immunohistochemistry & Molecular Morphology, vol. 20, no. 2, pp. 103–107, 2012. View at Publisher · View at Google Scholar
  38. N. Liu, X.-D. Fang, and Q. Vadis, “CD73 as a novel prognostic biomarker for human colorectal cancer,” Journal of Surgical Oncology, vol. 106, no. 7, pp. 918–919, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. X.-R. Wu, X.-S. He, Y.-F. Chen et al., “High expression of CD73 as a poor prognostic biomarker in human colorectal cancer,” Journal of Surgical Oncology, vol. 106, no. 2, pp. 130–137, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. X.-X. Lu, Y.-T. Chen, B. Feng, X.-B. Mao, B. Yu, and X.-Y. Chu, “Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma,” World Journal of Gastroenterology, vol. 19, no. 12, pp. 1912–1918, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Xiong, Y. Wen, X. Miao, and Z. Yang, “NT5E and FcGBP as key regulators of TGF-1-induced epithelial-mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer,” Cell and Tissue Research, vol. 355, no. 2, pp. 365–374, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. Q. Yang, J. Du, and L. Zu, “Overexpression of CD73 in prostate cancer is associated with lymph node metastasis,” Pathology and Oncology Research, vol. 19, no. 4, pp. 811–814, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Loi, S. Pommey, B. Haibe-Kains et al., “CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 27, pp. 11091–11096, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. L. F. Thompson, H. K. Eltzschig, J. C. Ibla et al., “Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia,” Journal of Experimental Medicine, vol. 200, no. 11, pp. 1395–1405, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Synnestvedt, G. T. Furuta, K. M. Comerford et al., “Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia,” The Journal of Clinical Investigation, vol. 110, no. 7, pp. 993–1002, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Kiss, G. G. Yegutkin, K. Koskinen, T. Savunen, S. Jalkanen, and M. Salmi, “IFN-β protects from vascular leakage via up-regulation of CD73,” European Journal of Immunology, vol. 37, no. 12, pp. 3334–3338, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. P. Vaupel, “The role of hypoxia-induced factors in tumor progression,” Oncologist, vol. 9, supplement 5, pp. 10–17, 2004. View at Google Scholar · View at Scopus
  48. S. P. Colgan, H. K. Eltzschig, T. Eckle, and L. F. Thompson, “Physiological roles for ecto-5′-nucleotidase (CD73),” Purinergic Signalling, vol. 2, no. 2, pp. 351–360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. R. R. Rackley, T. J. Lewis, E. M. Preston et al., “5′-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia,” Cancer Research, vol. 49, no. 13, pp. 3702–3707, 1989. View at Google Scholar · View at Scopus
  50. J. S. Damrauer, K. A. Hoadley, D. D. Chism et al., “Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 8, pp. 3110–3115, 2014. View at Publisher · View at Google Scholar · View at Scopus
  51. J. S. Kulkarni, D. A. Przywara, T. D. Wakade, and A. R. Wakade, “Adenosine induces apoptosis by inhibiting mRNA and protein synthesis in chick embryonic sympathetic neurons,” Neuroscience Letters, vol. 248, no. 3, pp. 187–190, 1998. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Saitoh, K. Nagai, K. Nakagawa, T. Yamamura, S. Yamamoto, and T. Nishizaki, “Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase,” Biochemical Pharmacology, vol. 67, no. 10, pp. 2005–2011, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. A. El-Darahali, H. Fawcett, J. S. Mader, D. M. Conrad, and D. W. Hoskin, “Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor,” Experimental and Molecular Pathology, vol. 79, no. 3, pp. 249–258, 2005. View at Publisher · View at Google Scholar · View at Scopus