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Disease Markers
Volume 2015, Article ID 792679, 6 pages
http://dx.doi.org/10.1155/2015/792679
Research Article

Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population

Laboratory of Biochemistry, UR 12ES08, Faculty of Medicine, 5000 Monastir, Tunisia

Received 7 July 2015; Revised 13 August 2015; Accepted 23 August 2015

Academic Editor: Fabrizia Bamonti

Copyright © 2015 Kaouthar Abid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant on cardiovascular risk factors in type 2 diabetic patients. The study population consisted of a control CAD group (101 patients) and 273 consecutive type 2 diabetic patients. Severity and extent of coronary atherosclerosis were scored numerically using the Gensini scoring system. The diabetic population was divided into three groups according to Gensini score: Group 1: no stenosis; Group 2: moderate CAD; Group 3, severe CAD. The homozygous CC genotype of rs1333049 was significantly associated with CAD in Group 2 (OR: 1.36; ) and Group 3 (OR: 5.77, ) compared to Group 1 (OR: 0.18; ) and control group (OR: 0.22; ). Among diabetic patients with early-onset CAD, CC genotype carriers had significantly higher Gensini scores than non-CC genotype carriers ( versus ; ). The homozygous CC genotype of rs1333049 confers a magnified risk of early-onset and severe CAD in type 2 diabetic Tunisian population.