Polymorphisms in C-Reactive Protein and Glypican-5 Are Associated with Lung Cancer Risk and Gartrokine-1 Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population
Table 6
Genotype and the allele frequencies of candidate genes in chemotherapy patients.
Genotype/allele
Responder
Nonresponder
ORa
95% CI
valuea
value adj.
%
%
rs2808630
T/T
25
71.43
64
82.05
1.000
T/C
9
25.71
10
12.82
0.434
0.158
1.194
0.142
0.994
C/C
1
2.86
4
5.13
1.652
0.166
14.670
0.791
1
T
59
84.29
138
88.46
C
11
15.71
18
13.04
0.700
0.311
1.572
0.386
1
rs1926203
G/G
23
65.71
55
70.51
1.000
G/T
12
34.29
17
21.79
0.592
0.245
1.435
0.244
1
T/T
0
0
6
7.70
#
#
#
0.999
1
G
58
82.86
127
81.41
T
12
17.14
29
18.59
1.104
0.526
2.316
0.989
1
rs2352028
C/C
22
72.86
57
73.08
1.000
C/T
13
37.14
21
26.92
0.623
0.267
1.457
0.221
1
T/T
0
0
0
0
—
—
—
—
C
57
81.43
135
86.54
T
13
18.57
21
13.46
0.682
0.320
1.455
0.269
1
rs8034191
T/T
34
97.14
74
94.87
1.000
T/C
1
2.86
4
5.13
1.838
0.198
17.068
0.477
1
C/C
0
0
0
0
—
—
—
—
T
69
98.57
152
97.44
C
1
1.43
4
2.56
1.816
0.199
16.547
0.485
1
rs9635542
A/A
10
28.57
20
25.64
1.000
G/A
17
48.57
37
47.44
1.088
0.420
2.819
0.866
1
G/G
8
22.86
21
26.92
1.312
0.431
3.996
0.809
1
A
38
54.29
76
48.72
G
32
45.71
80
51.28
1.250
0.710
2.200
0.619
1
rs4254535
T/T
28
80.00
46
58.97
1.000
C/T
5
14.29
27
34.62
3.287
1.135
9.522
0.029
0.203
C/C
2
5.71
5
6.41
1.522
0.276
8.378
0.901
1
T
61
87.14
119
76.28
C
9
12.86
37
23.72
2.107
0.955
4.649
0.109
0.763
rs1530057
C/C
33
94.29
71
91.03
1.000
C/A
2
5.71
7
95.51
1.627
0.320
8.260
0.659
1
A/A
0
0
0
0
—
—
—
—
C
68
97.14
149
95.51
A
2
2.86
7
4.49
1.597
0.323
7.891
0.671
1
value ≤ 0.05 indicates statistical significance; OR: odds ratio; CI: confidence interval.
aAdjusted by age, gender, smoke status, histology, stage, and chemotherapy regimens.
#When a factor cell associated with the odds ratio is zero, extremely high odds ratios may occur, and it is the same with extremely low odds ratios. It is because the algorithm estimating the logistic coefficient (and hence also exp., the odds ratio) is unstable, failing to converge while attempting to move iteratively toward positive infinity (or negative infinity). — Some of the mutated genotypes do not exist in the study subjects, so the relative statistics cannot be calculated. value was adjusted by Bonferroni correction.
