Figure 1: Pedigree of the three-generation Belgian family. The genotypes of 5 markers within and surrounding the linked region on chromosome 8 are depicted. The haplotype cosegregating with the EDS-HT phenotype is indicated with a black bar. An arrow indicates the proband. Individuals included in the initial genome-wide linkage screen are indicated with an asterisk. Affected and unaffected individuals are indicated with a black or white pictogram, respectively, whereas a grey pictogram with a question mark points to a patient for whom the phenotype was not clear (unknown).