First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach

Table 4

Detection rates (DR) at a fixed 10% false positive rate (FPR) and -statistics (AUC) for various prediction models based on selected markers. Only models that improved the performance of the baseline model (prior risk + MAP) were used in the validation set.

Model	Training set		Test set		Validation set
EO-PE	DR (95% CI)	AUC	DR (95% CI)	AUC	DR (95% CI)	AUC
Prior risk + MAP	55 (35–80)	0.879	81 (50–100)	0.914	45 (25–70)	0.720
Prior risk + MAP + hexanoylcarnitine	60 (35–80)	0.887	69 (38–94)	0.897	—	—
Prior risk + MAP + octenoylcarnitine	60 (35–80)	0.875	75 (50–94)	0.913	—	—
Prior risk + MAP + octanoylcarnitine	60 (35–80)	0.881	75 (44–100)	0.909	—	—
Prior risk + MAP + decenoylcarnitine	60 (35–80)	0.879	75 (44–100)	0.915	—	—
Prior risk + MAP + decanoylcarnitine	60 (35–80)	0.882	75 (44–100)	0.908	—	—
Prior risk + MAP + dodecenoylcarnitine	55 (35–80)	0.883	75 (44–100)	0.910	—	—
Prior risk + MAP + tetradecenoylcarnitine	60 (40–80)	0.885	75 (44–94)	0.905	—	—
Prior risk + MAP + linoleylcarnitine	55 (35–80)	0.879	81 (50–100)	0.915	—	—
Prior risk + MAP + stearoylcarnitine	60 (35–80)	0.877	88 (63–100)	0.935	50 (25–70)	0.747
Prior risk + MAP + PAPPA + PlGF	58 (32–84)	0.884	—	—	56 (31–81)	0.727
Prior risk + MAP + PAPPA + PlGF + stearoylcarnitine	68 (42–84)	0.883	—	—	56 (31–81)	0.751
Prior risk + MAP + PAPPA + PlGF + stearoylcarnitine + taurine	68 (42–89)	0.878	—	—	69 (38–88)	0.784
LO-PE	DR (95% CI)	AUC	DR (95% CI)	AUC	DR (95% CI)	AUC
Prior risk + MAP	46 (23–71)	0.816	46 (29–67)	0.790	21 (4–42)	0.652
Prior risk + MAP + hexanoylcarnitine	49 (29–69)	0.824	46 (21–71)	0.787	—	—
Prior risk + MAP + octenoylcarnitine	54 (31–71)	0.822	50 (25–75)	0.788	—	—
Prior risk + MAP + octanoylcarnitine	49 (29–69)	0.820	42 (21–71)	0.784	—	—
Prior risk + MAP + decenoylcarnitine	49 (31–69)	0.823	42 (25–67)	0.785	—	—
Prior risk + MAP + decanoylcarnitine	46 (29–69)	0.818	46 (21–67)	0.785	—	—
Prior risk + MAP + dodecenoylcarnitine	46 (26–66)	0.815	42 (25–67)	0.790	—	—
Prior risk + MAP + tetradecenoylcarnitine	43 (26–66)	0.821	42 (21–63)	0.789	—	—
Prior risk + MAP + linoleylcarnitine	46 (23–71)	0.816	50 (29–71)	0.799	—	—
Prior risk + MAP + stearoylcarnitine	49 (26–77)	0.828	54 (29–79)	0.820	29 (8–46)	0.692
Prior risk + MAP + stearoylcarnitine + linoleylcarnitine	57 (34–77)	0.829	50 (25–75)	0.815	—	—
Prior risk + MAP + PAPPA + PlGF	55 (36–70)	0.825	—	—	27 (9–55)	0.688
Prior risk + MAP + PAPPA + PlGF + stearoylcarnitine	58 (36–79)	0.833	—	—	32 (9–64)	0.700

MAP: mean arterial pressure; CI: confidence interval; AUC: area under the curve; EO-PE: early-onset-preeclampsia; LO-PE: late-onset-preeclampsia.