The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage

Table 6

Loading scores of variables on the first three significant principal components.

	Component 1	Component 2	Component 3	Component 4
ZO-1 (pg/mL)	0.882	0.041	0.136	0.058
MMP-9 (ng/mL)	0.869	−0.104	0.189	0.185
CLDN5 (pg/mL)	0.847	0.114	0.090	0.181
ALB (g/L)	0.750	0.086	0.464	−0.017
VEGF (ng/mL)	0.582	−0.307	−0.178	−0.224
OCLN (pg/mL)	0.457	−0.150	0.383	−0.565
ZO-1 (pg/mL)	0.356	0.506	−0.503	0.028
CLDN5 (pg/mL)	0.355	0.278	−0.801	−0.061
OCLN (pg/mL)	0.279	0.690	−0.238	0.309
WBC (/L)	−0.184	−0.005	0.458	0.743
DBP (mmHg)	−0.204	0.756	0.469	−0.194
SBP (mmHg)	−0.221	0.803	0.318	−0.269

Bold values indicate strong and moderate loadings: Component 1 has strong positive loadings on ZO-1, MMP-9, CLDN5, Alb, VEGF, and OCLN; Component 2 has positive loadings on ZO-1, OCLN, DBP, and SBP; Component 3 has positive loadings on WBC, DBP and negative loadings on ZO-1, CLDN5; Component 4 has positive loadings on WBC and negative loadings on OCLN.