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Disease Markers
Volume 2015, Article ID 860628, 7 pages
http://dx.doi.org/10.1155/2015/860628
Research Article

NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population

1Laboratorio de Fisiopatología, Centro de Medicina Experimental “Miguel Layrisse”, Instituto Venezolano de Investigaciones Científicas, Kilómetro 11 Carretera Panamericana, Apartado 21827, Caracas 1020A, Distrito Capital, Venezuela
2Laboratorio de Genética Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Kilómetro 11 Carretera Panamericana, Apartado 21827, Caracas 1020A, Distrito Capital, Venezuela
3Unidad de Tórax, Hospital Dr. José Ignacio Baldó “El Algodonal”, Avenida Intercomunal de Antímano, La Yaguara, Apartado 1000, Caracas 1020A, Distrito Capital, Venezuela

Received 5 March 2015; Accepted 17 September 2015

Academic Editor: Irene Rebelo

Copyright © 2015 Mercedes Fernández-Mestre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Natural resistance-associated macrophage protein (Nramp1) and the vitamin D receptor (VDR) are central components of the innate and adaptive immunity against Mycobacterium tuberculosis, and associations between susceptibility to tuberculosis and polymorphisms in the genes NRAMP and VDR have been sought in geographically diverse populations. We investigated associations of NRAMP1 and VDR gene polymorphisms with susceptibility to TB in the Venezuelan population. The results suggest the absence of any association between VDR variants FokI, ApaI, and TaqI and susceptibility to tuberculosis. In contrast, the NRAMP1 3′UTR variants were associated with susceptibility to M. tuberculosis infection, as seen in the comparisons between TST+ and TST− controls, and also with progression to TB disease, as shown in the comparisons between TB patients and TST+ controls. This study confirms the previously described association of the NRAMP1 3′UTR polymorphism with M. tuberculosis infection and disease progression.