Bone Marrow Stromal Antigen 2 Is a Novel Plasma Biomarker and Prognosticator for Colorectal Carcinoma: A Secretome-Based Verification Study

Table 1

Multivariate analysis of BST2 tissue expression levels and clinicopathologic factors of 132 CRC patients.

Variable	HR	95% CI	value
Gender
Male	1
Female	0.70	0.42~1.17	0.17
Age (years)
<65	1
≧65	1.91	1.18~3.11	<0.01
TNM stage
Early (I~II)	1
Late (III~IV)	3.29	1.94~5.58	<0.01
Differentiation
Well	1
Moderate	1.25	0.66~2.36	0.01
Poor	1.77	0.55~5.69
Histological type
Adenocarcinoma	1
Mucinous carcinoma	1.82	0.65~5.14	0.25
Chemotherapy
Yes	1
No	1.40	0.80~2.46	0.23
CEA (ng/mL)
<5	1
≧5	2.02	1.21~3.37	<0.01
BST2 (IHC score)
Low (0–149)	1
High (150–300)	1.64	0.98~2.74	0.05

HR: hazard ratio.
CI: confidence interval.