Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms

Table 1

Characteristics of the studies on miR-200c included in this meta-analysis.

Author	Publication year	Origin of population	Number of cases	Cancer; type	Sample	Test method	Cut-off	Survival analysis	Estimated HR	Prognosis
Cao et al. [22]	2014	China	100	Ovarian cancer	Tissue	qRT-PCR	Median	OS	Reported	Negative
Lin et al. [23]	2014	Australia	97	Prostate cancer	Serum	qRT-PCR	Median	OS	Reported	Negative
Yu et al. [24]	2013	China	157	Esophageal cancer	Serum	qRT-PCR	Median	OS	Reported	Negative
Tanaka et al. [25]	2013	Japan	64	Esophageal cancer	Serum	qRT-PCR	Median	PFS	Reported	Negative
Diaz et al. [26]	2014	Spain	127	Colorectal cancer	Tissue	qRT-PCR	NA	OS; DFS	Estimated	Positive
Valladares-Ayerbes; et al. [27]	2012	Spain	52	Gastric cancer	Blood	qRT-PCR	Mean	OS; PFS	Estimated	Negative
Marchini et al. [28]	2011	Italy	89; 55	Ovarian cancer	Tissue	qRT-PCR	25th quartiles	OS; PFS	Reported	Positive
Karaayvaz et al. [20]	2012	America	34	Endometrial cancer	Tissue	qRT-PCR	dCT = 35.5	OS	Reported	Positive
Toiyama et al. [29]	2014	Japan	156; 182	Colorectal cancer	Tissue; serum	qRT-PCR	ROC	OS; PFS	Reported	Positive; negative
Tang et al. [30]	2013	China	126	Gastric cancer	Tissue	ISH	An SI score of 2	OS; DFS	Estimated	Positive
Tejero et al. [31]	2014	Spain	155	Lung cancer	Tissue	qRT-PCR	NA	OS	Estimated	Negative
Liu et al. [32]	2012	China	70	Lung cancer	Tissue	qRT-PCR	2-fold	OS	Reported	Negative
Hamano et al. [33]	2011	Japan	98	Esophageal cancer	Tissue	qRT-PCR	Median	OS	Estimated	Negative
Yu et al. [34]	2010	Japan	99	Pancreatic cancer	Tissue	qRT-PCR	Value = 0.64	OS	Reported	Positive
Kim et al. [35]	2014	South Korea	72	Lung cancer	Tissue	qRT-PCR	Median	OS	Estimated	Positive
Li et al. [36]	2014	China	150	Lung cancer	Tissue	qRT-PCR	55th percentiles	OS; PFS	Reported	Positive

qRT-PCR: quantitative real-time polymerase chain reaction; ISH: in situ hybridization; NA: not available; ROC: receiver operating characteristic; SI (staining index score): combing staining intensity and proportion of positively stained cells; OS: overall survival; DFS: disease-free survival; PFS: progression-free survival.