Genome-Wide Scan for Methylation Profiles in Keloids

Table 1

Breakdown of 685 differentially methylated Tier 3 CpGs¹.

A: methylation status of 685 CpGs
Hypermethylated	175 (26%)
Hypomethylated	510 (74%)
B: 685-CpG distribution in promoter versus nonpromoter
Promoter	190 (28%)
Nonpromoter	495 (72%)
C: methylation status of 190 promoter CpGs
Hypermethylated	62 (33%)
Hypomethylated	128 (67%)
D: 190-CpG distribution in promoter regions
TSS200	29%
TSS1500	26%
5′UTR	41%
First exon	4%
E: methylation status of 152 genes associated with the 190 CpGs
Hypermethylated	56 (37%)
Hypomethylated	96 (63%)

CpG (cytosine-phosphodiester bond-guanine); TSS (transcription start site); UTR (untranslated region).