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Disease Markers
Volume 2016, Article ID 1545974, 20 pages
http://dx.doi.org/10.1155/2016/1545974
Review Article

Association of Common Variants in MMPs with Periodontitis Risk

1Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences and College of Stomatology, Chongqing Medical University, Chongqing 400016, China
2Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

Received 5 December 2015; Revised 18 February 2016; Accepted 16 March 2016

Academic Editor: Jacek Kurzepa

Copyright © 2016 Wenyang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. O. Costa, A. N. Guimarães, L. O. M. Cota et al., “Impact of different periodontitis case definitions on periodontal research,” Journal of oral science, vol. 51, no. 2, pp. 199–206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Endo, T. Watanabe, N. Ogata et al., “Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease,” ISME Journal, vol. 9, no. 3, pp. 629–642, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. U. M. Irfan, D. V. Dawson, and N. F. Bissada, “Epidemiology of periodontal disease: a review and clinical perspectives,” Journal of the International Academy of Periodontology, vol. 3, no. 1, pp. 14–21, 2001. View at Google Scholar · View at Scopus
  4. R. P. Verma and C. Hansch, “Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs,” Bioorganic and Medicinal Chemistry, vol. 15, no. 6, pp. 2223–2268, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. L. Lauer-Fields, D. Juska, and G. B. Fields, “Matrix metalloproteinases and collagen catabolism,” Biopolymers, vol. 66, no. 1, pp. 19–32, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. B. S. Sekhon, “Matrix metalloproteinases—an overview,” Research and Reports in Biology, vol. 1, pp. 1–20, 2010. View at Google Scholar
  7. A. Letra, R. M. Silva, R. J. Rylands et al., “MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression,” Journal of Clinical Periodontology, vol. 39, no. 8, pp. 707–716, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Gürkan, G. Emingil, B. H. Saygan et al., “Matrix metalloproteinase-2, -9, and -12 gene polymorphisms in generalized aggressive periodontitis,” Journal of Periodontology, vol. 78, no. 12, pp. 2338–2347, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Fontana, P. S. Silva, R. F. Gerlach, and J. E. Tanus-Santos, “Circulating matrix metalloproteinases and their inhibitors in hypertension,” Clinica Chimica Acta, vol. 413, no. 7-8, pp. 656–662, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Li, Y. Yue, Y. Tian et al., “Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population,” Cytokine, vol. 60, no. 2, pp. 552–560, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. Y.-H. Chou, Y.-P. Ho, Y.-C. Lin et al., “MMP-8 -799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese,” Journal of Clinical Periodontology, vol. 38, no. 12, pp. 1078–1084, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. G. C. Keles, S. Gunes, A. P. Sumer et al., “Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis,” Journal of Periodontology, vol. 77, no. 9, pp. 1510–1514, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. Z. Cao, C. Li, and G. Zhu, “MMP-1 promoter gene polymorphism and susceptibility to chronic periodontitis in a Chinese population,” Tissue Antigens, vol. 68, no. 1, pp. 38–43, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. L. I. Holla, M. Jurajda, A. Fassmann, N. Dvorakova, V. Znojil, and J. Vacha, “Genetic variations in the matrix metalloproteinase-1 promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population,” Journal of Clinical Periodontology, vol. 31, no. 8, pp. 685–690, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. C. M. Astolfi, A. L. Shinohara, R. A. da Silva, M. C. L. G. Santos, S. R. P. Line, and A. P. de Souza, “Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population,” Journal of Clinical Periodontology, vol. 33, no. 10, pp. 699–703, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Chen, Q. Wang, Z.-W. Ma et al., “MMP-2, MMP-9andTIMP-2gene polymorphisms in Chinese patients with generalized aggressive periodontitis,” Journal of Clinical Periodontology, vol. 34, no. 5, pp. 384–389, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. M. Luczyszyn, C. M. De Souza, A. P. R. Braosi et al., “Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population,” Archives of Oral Biology, vol. 57, no. 7, pp. 954–963, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. C. E. Repeke, A. P. F. Trombone, S. B. Ferreira Jr. et al., “Strong and persistent microbial and inflammatory stimuli overcome the genetic predisposition to higher matrix metalloproteinase-1 (MMP-1) expression: a mechanistic explanation for the lack of association of MMP1-1607 single-nucleotide polymorphism genotypes with MMP-1 expression in chronic periodontitis lesions,” Journal of Clinical Periodontology, vol. 36, no. 9, pp. 726–738, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. W. T. Y. Loo, M. Wang, L. J. Jin, M. N. B. Cheung, and G. R. Li, “Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis,” Archives of Oral Biology, vol. 56, no. 10, pp. 1081–1090, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. A. P. de Souza, P. C. Trevilatto, R. M. Scarel-Caminaga, R. B. de Brito Jr., S. P. Barros, and S. R. P. Line, “Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis,” Journal of Clinical Periodontology, vol. 32, no. 2, pp. 207–211, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. D. M. Isaza-Guzmán, C. Arias-Osorio, M. C. Martínez-Pabón, and S. I. Tobón-Arroyave, “Salivary levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1: a pilot study about the relationship with periodontal status and MMP-9-1562C/T gene promoter polymorphism,” Archives of Oral Biology, vol. 56, no. 4, pp. 401–411, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Itagaki, T. Kubota, H. Tai et al., “Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis,” Journal of Clinical Periodontology, vol. 31, no. 9, pp. 764–769, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. L. I. Holla, A. Fassmann, A. Vasku et al., “Genetic variations in the human gelatinase A (matrix metalloproteinase-2) promoter are not associated with susceptibility to, and severity of, chronic periodontitis,” Journal of Periodontology, vol. 76, no. 7, pp. 1056–1060, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. L. I. Holla, A. Fassmann, J. Mužik, J. Vanek, and A. Vasku, “Functional polymorphisms in the matrix metalloproteinase-9 gene in relation to severity of chronic periodontitis,” Journal of Periodontology, vol. 77, no. 11, pp. 1850–1855, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Gürkan, G. Emingil, B. H. Saygan et al., “Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis,” Archives of Oral Biology, vol. 53, no. 4, pp. 337–345, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Pirhan, G. Atilla, G. Emingil, T. Sorsa, T. Tervahartiala, and A. Berdeli, “Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis,” Journal of Clinical Periodontology, vol. 35, no. 10, pp. 862–870, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Ustun, N. Ö. Alptekin, S. S. Hakki, and E. E. Hakki, “Investigation of matrix metalloproteinase-1—1607 1G/2G polymorphism in a Turkish population with periodontitis,” Journal of Clinical Periodontology, vol. 35, no. 12, pp. 1013–1019, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Pirhan, G. Atilla, G. Emingil, T. Tervahartiala, T. Sorsa, and A. Berdeli, “MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy,” Journal of Clinical Periodontology, vol. 36, no. 6, pp. 474–481, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. L. I. Holla, B. Hrdlickova, J. Vokurka, and A. Fassmann, “Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis,” Archives of Oral Biology, vol. 57, no. 2, pp. 188–196, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Emingil, B. Han, A. Gürkan et al., “Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy,” Journal of Periodontology, vol. 85, no. 8, pp. 1070–1080, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. A. P. de Souza, P. C. Trevilatto, R. M. Scarel-Caminaga, R. B. Brito Jr., and S. R. P. Line, “MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population,” Journal of Clinical Periodontology, vol. 30, no. 2, pp. 154–158, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. Cao, C. Li, L. Jin, and E. F. Corbet, “Association of matrix metalloproteinase-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese population,” Journal of Periodontal Research, vol. 40, no. 6, pp. 427–431, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. J. L. Rutter, T. I. Mitchell, G. Butticè et al., “A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription,” Cancer Research, vol. 58, no. 23, pp. 5321–5325, 1998. View at Google Scholar · View at Scopus
  34. M. D. Sternlicht and Z. Werb, “How matrix metalloproteinases regulate cell behavior,” Annual Review of Cell and Developmental Biology, vol. 17, pp. 463–516, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Kasamatsu, K. Uzawa, K. Shimada et al., “Elevation of galectin-9 as an inflammatory response in the periodontal ligament cells exposed to Porphylomonas gingivalis lipopolysaccharide in vitro and in vivo,” International Journal of Biochemistry and Cell Biology, vol. 37, no. 2, pp. 397–408, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Rossa Jr., L. Min, P. Bronson, and K. L. Kirkwood, “Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase,” Journal of Endotoxin Research, vol. 13, no. 2, pp. 85–93, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. S. A. Dowsett, L. Archila, T. Foroud, D. Koller, G. J. Eckert, and M. J. Kowolik, “The effect of shared genetic and environmental factors on periodontal disease parameters in untreated adult siblings in Guatemala,” Journal of Periodontology, vol. 73, no. 10, pp. 1160–1168, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. Q. Meng, V. Malinovskii, W. Huang et al., “Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate,” Journal of Biological Chemistry, vol. 274, no. 15, pp. 10184–10189, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. Y.-C. Chang, S.-F. Yang, C.-C. Lai, J.-Y. Liu, and Y.-S. Hsieh, “Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures,” Journal of Periodontal Research, vol. 37, no. 3, pp. 196–203, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. L. X. Shen, J. P. Basilion, and V. P. Stanton Jr., “Single-nucleotide polymorphisms can cause different structural folds of mRNA,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 14, pp. 7871–7876, 1999. View at Publisher · View at Google Scholar · View at Scopus
  41. A. C. Pereira, E. Dias do Carmo, M. A. Dias da Silva, and L. E. Blumer Rosa, “Matrix metalloproteinase gene polymorphisms and oral cancer,” Journal of Clinical and Experimental Dentistry, vol. 4, no. 5, pp. e297–e301, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Rollin, S. Régina, P. Vourc'h et al., “Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer,” Lung Cancer, vol. 56, no. 2, pp. 273–280, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Li, D.-L. Sun, Y.-N. Duan et al., “Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China,” Molecular Biology Reports, vol. 37, no. 1, pp. 197–205, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Saracini, P. Bolli, E. Sticchi et al., “Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm,” Journal of Vascular Surgery, vol. 55, no. 1, pp. 171–179.e2, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Yu, Y. Zhou, X. Miao, P. Xiong, W. Tan, and D. Lin, “Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer,” Cancer Research, vol. 64, no. 20, pp. 7622–7628, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. M. R. Luizon and V. de Almeida Belo, “Matrix metalloproteinase (MMP)-2 and MMP-9 polymorphisms and haplotypes as disease biomarkers,” Biomarkers, vol. 17, no. 3, pp. 286–288, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. S. B. Kondapaka, R. Fridman, and K. B. Reddy, “Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells,” International Journal of Cancer, vol. 70, no. 6, pp. 722–726, 1997. View at Publisher · View at Google Scholar · View at Scopus
  48. B. Zhang, S. Ye, S.-M. Herrmann et al., “Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis,” Circulation, vol. 99, no. 14, pp. 1788–1794, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. T.-S. Huang, C.-C. Lee, A.-C. Chang et al., “Shortening of microsatellite deoxy(CA) repeats involved in GL331-induced down-regulation of matrix metalloproteinase-9 gene expression,” Biochemical and Biophysical Research Communications, vol. 300, no. 4, pp. 901–907, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. K. Komosinska-Vassev, P. Olczyk, K. Winsz-Szczotka, K. Kuznik-Trocha, K. Klimek, and K. Olczyk, “Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 level,” Gerontology, vol. 57, no. 1, pp. 44–52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. R. C. Borghaei, P. L. Rawlings Jr., M. Javadi, and J. Woloshin, “NF-κB binds to a polymorphic repressor element in the MMP-3 promoter,” Biochemical and Biophysical Research Communications, vol. 316, no. 1, pp. 182–188, 2004. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Decock, J.-R. Long, R. C. Laxton et al., “Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis,” Cancer Research, vol. 67, no. 21, pp. 10214–10221, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. A. M. Heikkinen, T. Sorsa, J. Pitkäniemi et al., “Smoking affects diagnostic salivary periodontal disease biomarker levels in adolescents,” Journal of Periodontology, vol. 81, no. 9, pp. 1299–1307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. H. Ilumets, P. Rytilä, I. Demedts et al., “Matrix metalloproteinases -8, -9 and -12 in smokers and patients with Stage 0 COPD,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 2, no. 3, pp. 369–379, 2007. View at Google Scholar · View at Scopus
  55. K.-Z. Liu, A. Hynes, A. Man, A. Alsagheer, D. L. Singer, and D. A. Scott, “Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1762, no. 8, pp. 775–780, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. Z. Zhou, S. S. Apte, R. Soininen et al., “Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 8, pp. 4052–4057, 2000. View at Publisher · View at Google Scholar · View at Scopus
  57. D. Li, Q. Cai, L. Ma et al., “Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis,” PLoS ONE, vol. 8, no. 3, Article ID e59513, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. Y. Pan, D. Li, Q. Cai et al., “MMP-9 -1562C>T contributes to periodontitis susceptibility,” Journal of Clinical Periodontology, vol. 40, no. 2, pp. 125–130, 2013. View at Publisher · View at Google Scholar · View at Scopus