Association of Common Variants in MMPs with Periodontitis Risk

Table 1

Main Characteristics of included studies.

Author, year	Country	Ethnicity	Sample size; (case/control)	Type of periodontitis	Matching criteria	Genotype method	Gene (polymorphism) & HWE in controls
de Souza et al., 2003 [31]	Brazil	Caucasian	50/37	CP (moderate or severe)	Smoker ratios	PCR-RFLP	MMP-1 (−1607 1G/2G) 0.87
Holla et al., 2004 [14]	Czech Republic	Caucasian	133/196	CP (mild to moderate to severe)	Age, gender	PCR-RFLP	MMP-1 (−1607 1G/2G) 0.52; MMP-1 (−519 A/G) 0.11; MMP-1 (−422 A/T) 0.47
Itagaki et al., 2004 [22]	Japan	Asian	205/142	CP (mild or moderate or severe)	Age, gender, smoker ratios	TaqMan	MMP-1 (−1607 1G/2G) 0.48; MMP-3 (−1171 5A/6A) 0.87
			37/142	AgP
Holla et al., 2005 [23]	Czech Republic	Caucasian	149/127	CP (mild to moderate to severe)	Age, smoker ratios	PCR-RFLP	MMP-2 (−1575 G/A) 0.40; MMP-2 (−1306 C/T) 0.19; MMP-2 (−790 T/G) 0.67; MMP-2 (−735 C/T) 0.42
Cao et al., 2005 [32]	China	Asian	40/52	AgP	—	PCR-RFLP	MMP-1 (−1607 1G/2G) 0.78
Cao et al., 2006 [13]	China	Asian	60/50	CP (moderate or severe)	—	PCR-RFLP	MMP-1 (−1607 1G/2G) 0.99
Keles et al., 2006 [12]	Turkey	Caucasian	70/70	CP (severe)	Age, gender	PCR-RFLP	MMP-9 (−1562 C/T) 0.82
Holla et al., 2006 [24]	Czech Republic	Caucasian	169/135	CP (moderate or severe)	Age, gender, smoker ratios	PCR-RFLP	MMP-9 (−1562 C/T) 0.59; MMP-9 (+279 R/Q) 0.25
Chen et al., 2007 [16]	China	Asian	79/128	AgP	Age, gender	DHPLC; PCR-RFLP	MMP-2 (−1306 C/T) 1.00; MMP-9 (−1562 C/T) 0.63
Gürkan et al., 2007 [8]	Turkey	Caucasian	92/157	AgP	Gender	PCR-RFLP	MMP-2 (−735 C/T) 0.45; MMP-9 (−1562 C/T) 0.35; MMP-12 (357 Asn/Ser) 0.06
Gürkan et al., 2008 [25]	Turkey	Caucasian	87/107	CP (severe)	—	PCR-RFLP	MMP-2 (−735 C/T) 0.43; MMP-12 (357 Asn/Ser) 0.47
Pirhan et al., 2008 [26]	Turkey	Caucasian	102/98	CP (severe)	—	PCR-RFLP	MMP-1 (−519 A/G) 0.79
Ustun et al., 2008 [27]	Turkey	Caucasian	126/54	CP (moderate or severe)	Age	PCR-RFLP	MMP-1 (−1607 1G/2G) 0.75
Pirhan et al., 2009 [28]	Turkey	Caucasian	102/98	CP (severe)	—	PCR-RFLP	MMP-13 (−77 A/G) 0.89; MMP-13 (11A/12A) 0.92
Chou et al., 2011 [11]	China	Asian	361/106	CP (moderate to severe)	Gender, smoker ratios	PCR-RFLP	MMP-8 (−799 C/T) 0.22
			96/106	AgP
Holla et al., 2012 [29]	Czech Republic	Caucasian	341/278	CP (mild to moderate to severe)	Age, gender, smoker ratios	PCR-RFLP	MMP-8 (+17 C/G) 0.14; MMP-8 (−799 C/T) 0.63
Emingil et al., 2014 [30]	Turkey	Caucasian	100/167	AgP	Gender	PCR-RFLP	MMP-8 (+17 C/G) 0.29; MMP-8 (−799 C/T) 0.09; MMP-8 (−381 A/G) 0.87

CP: chronic periodontitis; AgP: aggressive periodontitis; HWE: Hardy-Weinberg equilibrium. Mild chronic periodontitis: patients with teeth exhibiting < 3 mm attachment loss; moderate chronic periodontitis: patients with teeth exhibiting ≥ 3 mm and <7 mm attachment loss; severe chronic periodontitis: patients with teeth exhibiting ≥ 7 mm attachment loss. A value less than 0.05 of HWE was considered significant.