Disease Markers

Review Article

Association of Common Variants in MMPs with Periodontitis Risk

Table 2

Assessing the quality of included studies.
Author, yearSelectionComparabilityExposureScore
de Souza et al., 2003 [31]☆  ☆☆ ☆☆ 5
Holla et al., 2004 [14]☆ ☆☆☆☆☆☆ 7
Itagaki et al., 2004 [22]☆  ☆☆☆☆☆ 6
Holla et al., 2005 [23]☆ ☆☆☆☆☆☆ 7
Cao et al., 2005 [32]☆  ☆☆ ☆☆ 5
Cao et al., 2006 [13]☆  ☆☆ ☆☆ 5
Keles et al., 2006 [12]☆☆☆☆☆ ☆☆ 7
Holla et al., 2006 [24]☆☆☆☆☆☆☆☆☆ 9
Chen et al., 2007 [16]☆ ☆☆☆☆☆☆☆ 8
Gürkan et al., 2007 [8]☆☆ ☆☆ ☆☆☆ 7
Gürkan et al., 2008 [25]☆☆ ☆☆ ☆☆☆ 7
Pirhan et al., 2008 [26]☆☆ ☆☆☆☆☆☆8
Ustun et al., 2008 [27]☆  ☆☆ ☆☆ 5
Pirhan et al., 2009 [28]☆☆ ☆☆ ☆☆☆ 7
Chou et al., 2011 [11]☆☆ ☆☆☆☆☆ 7
Holla et al., 2012 [29]☆☆☆☆☆☆☆☆ 8
Emingil et al., 2014 [30]☆☆ ☆☆☆☆☆ 7
Selection (1) Is the case definition adequate?
 (a) Yes, with independent validation ☆
 (b) Yes, for example, record linkage or based on self-reports
 (c) No description
(2) Representativeness of the cases
 (a) Consecutive or obviously representative series of cases ☆
 (b) Potential for selection biases or not stated
(3) Selection of controls
 (a) Community controls ☆
 (b) Hospital controls
 (c) No description
(4) Definition of controls
 (a) No history of disease (endpoint) ☆
 (b) No description of source
Comparability (1) Comparability of cases and controls on the basis of the design or analysis
 (a) Study controls for the most important factor (HWE in control group) ☆
 (b) Study controls for any additional factor (e.g., age, gender, and smoker ratios) ☆
Exposure (1) Ascertainment of exposure
 (a) Secure record ☆
 (b) Structured interview where blind to case/control status ☆
 (c) Interview not blinded to case/control status
 (d) Written self-report or medical record only
 (e) No description
(2) Same method of ascertainment for cases and controls
 (a) Yes ☆
 (b) No
(3) Nonresponse rate
 (a) Same rate for both groups ☆
 (b) Nonrespondents described
 (c) Rate different and no designation